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CLP1

CANCER ATLAS

Gene description

 Cleavage and polyadenylation factor I subunit 1

Protein class

 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA057770

GENE INFORMATION

Gene name

 CLP1 (HGNC Symbol)

Synonyms

 hClp1, HEAB

Description

 Cleavage and polyadenylation factor I subunit 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Clp1 family. The encoded protein is a multifunctional kinase which is a component of the tRNA splicing endonuclease complex and a component of the pre-mRNA cleavage complex II. This protein is implicated in tRNA, mRNA, and siRNA maturation. Mutations in this gene are associated with pontocerebellar hypoplasia type 10 (PCH10). Alternatively splice transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

Chromosome

 11

Cytoband

 q12.1

Chromosome location (bp)

 57648992 - 57661868

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172409 (version 83.38)

Entrez gene

 10978

UniProt

 Q92989 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92989

Antibodypedia

 CLP1 antibodies

PROTEIN BROWSER
CLP1-001
CLP1-002
CLP1-003
CLP1-004
CLP1-005
CLP1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLP1-001
ENSP00000434995
ENST00000533682
Q92989 [Direct mapping]
Polyribonucleotide 5'-hydroxyl-kinase Clp1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000214 [tRNA-intron endonuclease complex]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005849 [mRNA cleavage factor complex]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006378 [mRNA polyadenylation]
GO:0006379 [mRNA cleavage]
GO:0006388 [tRNA splicing, via endonucleolytic cleavage and ligation]
GO:0006777 [Mo-molybdopterin cofactor biosynthetic process]
GO:0008033 [tRNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016310 [phosphorylation]
GO:0021695 [cerebellar cortex development]
GO:0030423 [targeting of mRNA for destruction involved in RNA interference]
GO:0031124 [mRNA 3'-end processing]
GO:0035087 [siRNA loading onto RISC involved in RNA interference]
GO:0046404 [ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity]
GO:0051733 [polydeoxyribonucleotide kinase activity]
GO:0051736 [ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity]
Show all
 425 aa
47.6 kDa 		No 0
CLP1-002
ENSP00000436066
ENST00000525602
Q92989 [Direct mapping]
Polyribonucleotide 5'-hydroxyl-kinase Clp1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000214 [tRNA-intron endonuclease complex]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005849 [mRNA cleavage factor complex]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006378 [mRNA polyadenylation]
GO:0006379 [mRNA cleavage]
GO:0006388 [tRNA splicing, via endonucleolytic cleavage and ligation]
GO:0006777 [Mo-molybdopterin cofactor biosynthetic process]
GO:0008033 [tRNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016310 [phosphorylation]
GO:0021695 [cerebellar cortex development]
GO:0030423 [targeting of mRNA for destruction involved in RNA interference]
GO:0031124 [mRNA 3'-end processing]
GO:0035087 [siRNA loading onto RISC involved in RNA interference]
GO:0046404 [ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity]
GO:0051733 [polydeoxyribonucleotide kinase activity]
GO:0051736 [ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity]
Show all
 425 aa
47.6 kDa 		No 0
CLP1-003
ENSP00000304704
ENST00000302731
Q92989 [Direct mapping]
Polyribonucleotide 5'-hydroxyl-kinase Clp1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000214 [tRNA-intron endonuclease complex]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005849 [mRNA cleavage factor complex]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006378 [mRNA polyadenylation]
GO:0006379 [mRNA cleavage]
GO:0006388 [tRNA splicing, via endonucleolytic cleavage and ligation]
GO:0006777 [Mo-molybdopterin cofactor biosynthetic process]
GO:0008033 [tRNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016310 [phosphorylation]
GO:0021695 [cerebellar cortex development]
GO:0030423 [targeting of mRNA for destruction involved in RNA interference]
GO:0031124 [mRNA 3'-end processing]
GO:0035087 [siRNA loading onto RISC involved in RNA interference]
GO:0046404 [ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity]
GO:0051733 [polydeoxyribonucleotide kinase activity]
GO:0051736 [ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity]
Show all
 361 aa
40.7 kDa 		No 0
CLP1-004
ENSP00000433406
ENST00000529430
E9PL17 [Direct mapping]
Polyribonucleotide 5'-hydroxyl-kinase Clp1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000214 [tRNA-intron endonuclease complex]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005849 [mRNA cleavage factor complex]
GO:0006378 [mRNA polyadenylation]
GO:0006379 [mRNA cleavage]
GO:0006388 [tRNA splicing, via endonucleolytic cleavage and ligation]
GO:0006777 [Mo-molybdopterin cofactor biosynthetic process]
GO:0016310 [phosphorylation]
GO:0031124 [mRNA 3'-end processing]
GO:0035087 [siRNA loading onto RISC involved in RNA interference]
GO:0046404 [ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity]
GO:0051736 [ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity]
Show all
 436 aa
48.9 kDa 		No 0
CLP1-005
ENSP00000431744
ENST00000533905
E9PJM4 [Direct mapping]
Polyribonucleotide 5'-hydroxyl-kinase Clp1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006378 [mRNA polyadenylation]
GO:0006379 [mRNA cleavage]
Show all
 132 aa
14.9 kDa 		No 0
CLP1-006
ENSP00000435287
ENST00000529773
E9PKV5 [Direct mapping]
Polyribonucleotide 5'-hydroxyl-kinase Clp1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006378 [mRNA polyadenylation]
GO:0006379 [mRNA cleavage]
Show all
 92 aa
10.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.