Cell atlas - FUT9 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	FUT9
Gene description	Fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the microtubules, cytokinetic bridge & nucleoplasm.
RNA cell category	Cell line enhanced (SCLC-21H, RT4, SK-BR-3, MCF7)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Additional location	In addition localized to the Nucleoplasm (approved), Microtubules (approved), Cytokinetic bridge (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA070923
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, RT4, SK-BR-3, MCF7) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the microtubules, cytokinetic bridge & nucleoplasm.

Main location

Cytosol (approved)

Additional location

Nucleoplasm (approved), Microtubules (approved), Cytokinetic bridge (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
HPA070923	MCF7	Nucleoplasm
		Microtubules
		Cytokinetic bridge	Intensity	Intensity
HPA070923	RT4	Nucleoplasm
HPA070923	RT4	Cytosol
HPA070923	U-2 OS	Cytosol

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition
Intensity variation	Cytokinetic bridge

GENE INFORMATION
Gene name	FUT9 (HGNC Symbol)
Synonyms	Fuc-TIX
Description	Fucosyltransferase 9 (alpha (1,3) fucosyltransferase) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor polysaccharides. This protein is one of the few fucosyltransferases that synthesizes the LeX oligosaccharide (CD15) expressed in the organ buds progressing in mesenchyma during embryogenesis. It is also responsible for the expression of CD15 in mature granulocytes. A common haplotype of this gene has also been associated with susceptibility to placental malaria infection. [provided by RefSeq, Nov 2011]
Chromosome	6
Cytoband	q16.1
Chromosome location (bp)	96015984 - 96215612
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172461 (version 83.38)
Entrez gene	10690
UniProt	Q9Y231 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9Y231
Antibodypedia	FUT9 antibodies

PROTEIN BROWSER

FUT9-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FUT9-001 ENSP00000302599 ENST00000302103	Q9Y231 [Direct mapping] Alpha-(1,3)-fucosyltransferase 9 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0006486 [protein glycosylation] GO:0007399 [nervous system development] GO:0008417 [fucosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0032580 [Golgi cisterna membrane] GO:0036065 [fucosylation] GO:0042355 [L-fucose catabolic process] GO:0046920 [alpha-(1->3)-fucosyltransferase activity] Show all	359 aa 42.1 kDa	No	1