Expression of AGXT in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Alanine-glyoxylate aminotransferase

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA035370	HPA035371

GENE INFORMATION
Gene name	AGXT (HGNC Symbol)
Synonyms	AGT, AGT1, AGXT1, PH1, SPAT, SPT
Description	Alanine-glyoxylate aminotransferase (HGNC Symbol)
Entrez gene summary	This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q37.3
Chromosome location (bp)	240868479 - 240880502
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172482 (version 83.38)
Entrez gene	189
UniProt	P21549 (UniProt - Evidence at protein level)
neXtProt	NX_P21549
Antibodypedia	AGXT antibodies

PROTEIN BROWSER

AGXT-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AGXT-001 ENSP00000302620 ENST00000307503	P21549 [Direct mapping] Serine--pyruvate aminotransferase Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004760 [serine-pyruvate transaminase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005759 [mitochondrial matrix] GO:0005777 [peroxisome] GO:0005782 [peroxisomal matrix] GO:0007219 [Notch signaling pathway] GO:0008453 [alanine-glyoxylate transaminase activity] GO:0008483 [transaminase activity] GO:0009436 [glyoxylate catabolic process] GO:0010498 [proteasomal protein catabolic process] GO:0016597 [amino acid binding] GO:0019265 [glycine biosynthetic process, by transamination of glyoxylate] GO:0019448 [L-cysteine catabolic process] GO:0030170 [pyridoxal phosphate binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042803 [protein homodimerization activity] GO:0042853 [L-alanine catabolic process] GO:0042866 [pyruvate biosynthetic process] GO:0043621 [protein self-association] GO:0044281 [small molecule metabolic process] GO:0046487 [glyoxylate metabolic process] GO:0046724 [oxalic acid secretion] GO:0051384 [response to glucocorticoid] GO:0051591 [response to cAMP] Show all	392 aa 43 kDa	No	0