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Malignant cells displayed weak to moderate cytoplasmic staining with additional membranous positivity in a few cases of colorectal, pancreatic, ovarian and urothelial cancers. Occasional cases of colorectal, ovarian, cervical, urothelial and pancreatic cancers were strongly positive. Most cases of malignant gliomas, endometrial and renal cancers were negative.
GENE INFORMATION
Gene name
OR5T3 (HGNC Symbol)
Synonyms
OR5T3Q
Description
Olfactory receptor, family 5, subfamily T, member 3 (HGNC Symbol)
Entrez gene summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
