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HCFC1

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GENERAL INFORMATION

Gene name

 HCFC1

Gene description

 Host cell factor C1

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the mitochondria. In addition localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Mitochondria (supported)

Additional location

 In addition localized to the Nucleoplasm (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA018312
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the mitochondria. In addition localized to the nucleoplasm.

Main location

 Mitochondria (supported)

Additional location

 Nucleoplasm (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA018312 A-431 Nucleoplasm
Mitochondria
HPA018312 U-2 OS Nucleoplasm
Mitochondria
HPA018312 U-251 MG Nucleoplasm
Mitochondria

GENE INFORMATION

Gene name

 HCFC1 (HGNC Symbol)

Synonyms

 CFF, HCF-1, HCF1, HFC1, MGC70925, MRX3, PPP1R89, VCAF

Description

 Host cell factor C1 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 q28

Chromosome location (bp)

 153947553 - 153971807

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172534 (version 83.38)

Entrez gene

 3054

UniProt

 P51610 (UniProt - Evidence at protein level)

neXtProt

 NX_P51610

Antibodypedia

 HCFC1 antibodies

PROTEIN BROWSER
HCFC1-001
HCFC1-003
HCFC1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HCFC1-001
ENSP00000309555
ENST00000310441
P51610 [Direct mapping]
Host cell factor 1 HCF N-terminal chain 1 HCF N-terminal chain 2 HCF N-terminal chain 3 HCF N-terminal chain 4 HCF N-terminal chain 5 HCF N-terminal chain 6 HCF C-terminal chain 1 HCF C-terminal chain 2 HCF C-terminal chain 3 HCF C-terminal chain 4 HCF C-terminal chain 5 HCF C-terminal chain 6
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000123 [histone acetyltransferase complex]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0007049 [cell cycle]
GO:0010628 [positive regulation of gene expression]
GO:0016020 [membrane]
GO:0019046 [release from viral latency]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0042802 [identical protein binding]
GO:0043025 [neuronal cell body]
GO:0043254 [regulation of protein complex assembly]
GO:0043981 [histone H4-K5 acetylation]
GO:0043982 [histone H4-K8 acetylation]
GO:0043984 [histone H4-K16 acetylation]
GO:0043995 [histone acetyltransferase activity (H4-K5 specific)]
GO:0043996 [histone acetyltransferase activity (H4-K8 specific)]
GO:0045787 [positive regulation of cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046972 [histone acetyltransferase activity (H4-K16 specific)]
GO:0048188 [Set1C/COMPASS complex]
GO:0050821 [protein stabilization]
GO:0070461 [SAGA-type complex]
GO:0070688 [MLL5-L complex]
GO:0071339 [MLL1 complex]
GO:0071407 [cellular response to organic cyclic compound]
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 2035 aa
208.7 kDa 		No 0
HCFC1-003
ENSP00000359001
ENST00000369984
A6NEM2 [Direct mapping]
Host cell factor 1
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
Show all
 2080 aa
213.5 kDa 		No 0
HCFC1-004
ENSP00000399589
ENST00000444191
H7C1C4 [Direct mapping]
Host cell factor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 611 aa
63.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.