Cell atlas - MRPL52 - The Human Protein Atlas

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MRPL52

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	MRPL52
Gene description	Mitochondrial ribosomal protein L52
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA012319
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria.

Main location

Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA012319	A-431	Mitochondria
	HPA012319	U-2 OS	Mitochondria
	HPA012319	U-251 MG	Nucleoplasm	Intensity
	HPA012319	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	MRPL52
Synonyms
Description	Mitochondrial ribosomal protein L52 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which has no bacterial homolog. Multiple transcript variants encoding different protein isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	22829879 - 22835037
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172590 (version 83.38)
Entrez gene	122704
UniProt	Q86TS9 (UniProt - Evidence at protein level)
neXtProt	NX_Q86TS9
Antibodypedia	MRPL52 antibodies

PROTEIN BROWSER

MRPL52-001	MRPL52-003	MRPL52-005	MRPL52-006	MRPL52-014	MRPL52-015	MRPL52-016	MRPL52-017	MRPL52-018	MRPL52-019	MRPL52-020

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPL52-001 ENSP00000380633 ENST00000397496	Q86TS9 [Direct mapping] 39S ribosomal protein L52, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005743 [mitochondrial inner membrane] GO:0005762 [mitochondrial large ribosomal subunit] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0032543 [mitochondrial translation] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	122 aa 13.6 kDa	Yes	0
MRPL52-003 ENSP00000347277 ENST00000355151	Q86TS9 [Direct mapping] 39S ribosomal protein L52, mitochondrial Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005762 [mitochondrial large ribosomal subunit] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0032543 [mitochondrial translation] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	123 aa 13.7 kDa	No	0
MRPL52-005 ENSP00000380642 ENST00000397505	Q86TS9 [Direct mapping] 39S ribosomal protein L52, mitochondrial Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005743 [mitochondrial inner membrane] GO:0005762 [mitochondrial large ribosomal subunit] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0032543 [mitochondrial translation] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	87 aa 9.1 kDa	No	0
MRPL52-006 ENSP00000451832 ENST00000556465	G3V4J1 [Direct mapping] 39S ribosomal protein L52, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		72 aa 7.6 kDa	Yes	0
MRPL52-014 ENSP00000406655 ENST00000432849	G5E9P5 [Direct mapping] 39S ribosomal protein L52, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		110 aa 11.7 kDa	Yes	0
MRPL52-015 ENSP00000451809 ENST00000555536	G3V4H9 [Direct mapping] 39S ribosomal protein L52, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		52 aa 5.5 kDa	No	0
MRPL52-016 ENSP00000451303 ENST00000553711	Q86TS9 [Direct mapping] 39S ribosomal protein L52, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005743 [mitochondrial inner membrane] GO:0005762 [mitochondrial large ribosomal subunit] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0032543 [mitochondrial translation] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	64 aa 7.4 kDa	No	0
MRPL52-017 ENSP00000310762 ENST00000311892	A6NLB9 [Direct mapping] 39S ribosomal protein L52, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		52 aa 6.1 kDa	No	0
MRPL52-018 ENSP00000451081 ENST00000555345	Q86TS9 [Direct mapping] 39S ribosomal protein L52, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005743 [mitochondrial inner membrane] GO:0005762 [mitochondrial large ribosomal subunit] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0032543 [mitochondrial translation] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	64 aa 7.4 kDa	No	0
MRPL52-019 ENSP00000451436 ENST00000557221	G3V3U6 [Direct mapping] 39S ribosomal protein L52, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		51 aa 5.9 kDa	No	0
MRPL52-020 ENSP00000451481 ENST00000556840	Q86TS9 [Direct mapping] 39S ribosomal protein L52, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005743 [mitochondrial inner membrane] GO:0005762 [mitochondrial large ribosomal subunit] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0032543 [mitochondrial translation] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	64 aa 7.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.