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HOXC5

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GENERAL INFORMATION

Gene name

 HOXC5

Gene description

 Homeobox C5

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm.

RNA cell category

 Cell line enhanced (SH-SY5Y, AN3-CA)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA026794
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SH-SY5Y, AN3-CA)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm.

Main location

 Nucleoplasm (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA026794 A-431 Nucleoplasm
Cell Junctions
HPA026794 U-2 OS Nucleoplasm
HPA026794 U-251 MG Nucleoplasm

GENE INFORMATION

Gene name

 HOXC5 (HGNC Symbol)

Synonyms

 HOX3, HOX3D

Description

 Homeobox C5 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC5, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants have been described for HOXC5. The transcript variant which includes the shared exon apparently doesn't encode a protein. The protein-coding transcript variant contains gene-specific exons only. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 54032853 - 54035358

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172789 (version 83.38)

Entrez gene

 3222

UniProt

 Q00444 (UniProt - Inferred from homology)

neXtProt

 NX_Q00444

Antibodypedia

 HOXC5 antibodies

PROTEIN BROWSER
HOXC5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HOXC5-001
ENSP00000309336
ENST00000312492
Q00444 [Direct mapping]
Homeobox protein Hox-C5
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
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GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0009952 [anterior/posterior pattern specification]
GO:0030054 [cell junction]
GO:0043565 [sequence-specific DNA binding]
GO:0048706 [embryonic skeletal system development]
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 222 aa
25 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.