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OVOL1

GENERAL INFORMATION

Gene name

 OVOL1

Gene description

 Ovo-like zinc finger 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (esophagus, testis, skin)
GTEx:Tissue enhanced (skin, esophagus, testis)
FANTOM5:Tissue enhanced (esophagus, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, including squamous epithelial.

DATA RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA003984
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, testis, skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin, esophagus, testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, tonsil)

GENE INFORMATION

Gene name

 OVOL1 (HGNC Symbol)

Synonyms

 HOVO1

Description

 Ovo-like zinc finger 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a putative zinc finger containing transcription factor that is highly similar to homologous protein in Drosophila and mouse. Based on known functions in these species, this protein is likely involved in hair formation and spermatogenesis in human as well. [provided by RefSeq, Aug 2011]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 65787022 - 65797219

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172818 (version 83.38)

Entrez gene

 5017

UniProt

 O14753 (UniProt - Evidence at transcript level)

neXtProt

 NX_O14753

Antibodypedia

 OVOL1 antibodies

PROTEIN BROWSER
OVOL1-001
OVOL1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OVOL1-001
ENSP00000337862
ENST00000335987
O14753 [Direct mapping]
Putative transcription factor Ovo-like 1
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001822 [kidney development]
GO:0005634 [nucleus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007283 [spermatogenesis]
GO:0007498 [mesoderm development]
GO:0008544 [epidermis development]
GO:0043588 [skin development]
GO:0046872 [metal ion binding]
GO:0051729 [germline cell cycle switching, mitotic to meiotic cell cycle]
GO:1901994 [negative regulation of meiotic cell cycle phase transition]
GO:2000647 [negative regulation of stem cell proliferation]
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 267 aa
30.3 kDa 		No 0
OVOL1-002
ENSP00000434220
ENST00000532448
G3V1B0 [Direct mapping]
Ovo-like 1(Drosophila); Putative transcription factor Ovo-like 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
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 205 aa
23.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.