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RARG

CANCER ATLAS

Gene description

 Retinoic acid receptor, gamma

Protein class

 Cancer-related genes, FDA approved drug targets, Nuclear receptors, Plasma proteins, Predicted intracellular proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA053883

GENE INFORMATION

Gene name

 RARG (HGNC Symbol)

Synonyms

 NR1B3, RARC

Description

 Retinoic acid receptor, gamma (HGNC Symbol)

Entrez gene summary

 This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 53210567 - 53232980

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172819 (version 83.38)

Entrez gene

 5916

UniProt

 P13631 (UniProt - Evidence at protein level)

neXtProt

 NX_P13631

Antibodypedia

 RARG antibodies

PROTEIN BROWSER
RARG-001
RARG-004
RARG-005
RARG-011
RARG-012
RARG-017
RARG-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RARG-001
ENSP00000388510
ENST00000425354
P13631 [Direct mapping]
Retinoic acid receptor gamma
A8K3H3 [Target identity:100%; Query identity:100%]
Retinoic acid nuclear receptor gamma variant 1; Retinoic acid receptor gamma; Retinoic acid receptor, gamma, isoform CRA_b; cDNA FLJ75202, highly similar to Homo sapiens, retinoic acid receptor, gamma
Show all
Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001843 [neural tube closure]
GO:0002063 [chondrocyte development]
GO:0002068 [glandular epithelial cell development]
GO:0003406 [retinal pigment epithelium development]
GO:0003417 [growth plate cartilage development]
GO:0003430 [growth plate cartilage chondrocyte growth]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003708 [retinoic acid receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008361 [regulation of cell size]
GO:0009952 [anterior/posterior pattern specification]
GO:0010467 [gene expression]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0016021 [integral component of membrane]
GO:0031076 [embryonic camera-type eye development]
GO:0031641 [regulation of myelination]
GO:0032331 [negative regulation of chondrocyte differentiation]
GO:0032526 [response to retinoic acid]
GO:0035116 [embryonic hindlimb morphogenesis]
GO:0035264 [multicellular organism growth]
GO:0043010 [camera-type eye development]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043068 [positive regulation of programmed cell death]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045596 [negative regulation of cell differentiation]
GO:0045637 [regulation of myeloid cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046965 [retinoid X receptor binding]
GO:0048048 [embryonic eye morphogenesis]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0048608 [reproductive structure development]
GO:0048732 [gland development]
GO:0060041 [retina development in camera-type eye]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060173 [limb development]
GO:0060324 [face development]
GO:0060348 [bone development]
GO:0060349 [bone morphogenesis]
GO:0060429 [epithelium development]
GO:0060534 [trachea cartilage development]
GO:0060740 [prostate gland epithelium morphogenesis]
GO:0061037 [negative regulation of cartilage development]
GO:0070384 [Harderian gland development]
GO:0071300 [cellular response to retinoic acid]
Show all
 454 aa
50.3 kDa 		No 0
RARG-004
ENSP00000343698
ENST00000338561
P13631 [Direct mapping]
Retinoic acid receptor gamma
F1D8P1 [Target identity:100%; Query identity:100%]
Retinoic acid nuclear receptor gamma variant 2
Show all
Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008361 [regulation of cell size]
GO:0010467 [gene expression]
GO:0016021 [integral component of membrane]
GO:0032526 [response to retinoic acid]
GO:0035116 [embryonic hindlimb morphogenesis]
GO:0043065 [positive regulation of apoptotic process]
GO:0043068 [positive regulation of programmed cell death]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046965 [retinoid X receptor binding]
GO:0048048 [embryonic eye morphogenesis]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0060070 [canonical Wnt signaling pathway]
Show all
 443 aa
49.3 kDa 		No 0
RARG-005
ENSP00000444335
ENST00000543726
P13631 [Direct mapping]
Retinoic acid receptor gamma
Show all
Nuclear receptors
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008361 [regulation of cell size]
GO:0010467 [gene expression]
GO:0016021 [integral component of membrane]
GO:0032526 [response to retinoic acid]
GO:0035116 [embryonic hindlimb morphogenesis]
GO:0043065 [positive regulation of apoptotic process]
GO:0043068 [positive regulation of programmed cell death]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046965 [retinoid X receptor binding]
GO:0048048 [embryonic eye morphogenesis]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0060070 [canonical Wnt signaling pathway]
Show all
 432 aa
47.9 kDa 		No 0
RARG-011
ENSP00000454604
ENST00000551158
H3BMY6 [Direct mapping]
Retinoic acid receptor gamma
Show all
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Show all
 33 aa
3.2 kDa 		No 0
RARG-012
ENSP00000454385
ENST00000550362
H3BMH6 [Direct mapping]
Retinoic acid receptor gamma
Show all
Predicted intracellular proteins
Show all
 15 aa
1.5 kDa 		No 0
RARG-017
ENSP00000454417
ENST00000546717
H3BMK1 [Direct mapping]
Retinoic acid receptor gamma
Show all
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005654 [nucleoplasm]
Show all
 57 aa
5.9 kDa 		No 0
RARG-201
ENSP00000377947
ENST00000394426
P13631 [Direct mapping]
Retinoic acid receptor gamma
Show all
Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008361 [regulation of cell size]
GO:0010467 [gene expression]
GO:0016021 [integral component of membrane]
GO:0032526 [response to retinoic acid]
GO:0035116 [embryonic hindlimb morphogenesis]
GO:0043065 [positive regulation of apoptotic process]
GO:0043068 [positive regulation of programmed cell death]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046965 [retinoid X receptor binding]
GO:0048048 [embryonic eye morphogenesis]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0060070 [canonical Wnt signaling pathway]
Show all
 382 aa
42.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.