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Cancer tissues displayed moderate to strong cytoplasmic and nuclear positivity. Several cases of malignant melanoma, renal, liver and testicular cancers were weakly stained or negative.
Most cancer cells showed weak to moderate cytoplasmic staining, often with additional membranous immunoreactivity. Rare hepatocellular carcinomas and endometrial cancers were strongly stained. Several gliomas were negative.
GENE INFORMATION
Gene name
CES3 (HGNC Symbol)
Synonyms
ES31, FLJ21736
Description
Carboxylesterase 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010]
