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Malignant cells showed a variable staining pattern, either weakly or strongly positive in nuclei. Strong nuclear staining was registered in rare cases of endometrial and renal carcinomas, and in malignant gliomas and lymphomas. Tumors of the breast, prostate and stomach were generally weakly stained.
GENE INFORMATION
Gene name
SP3 (HGNC Symbol)
Synonyms
SPR-2
Description
Sp3 transcription factor (HGNC Symbol)
Entrez gene summary
This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010]
Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001503 [ossification] GO:0001701 [in utero embryonic development] GO:0001779 [natural killer cell differentiation] GO:0001829 [trophectodermal cell differentiation] GO:0001889 [liver development] GO:0001892 [embryonic placenta development] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016605 [PML body] GO:0017053 [transcriptional repressor complex] GO:0030183 [B cell differentiation] GO:0030217 [T cell differentiation] GO:0030218 [erythrocyte differentiation] GO:0030219 [megakaryocyte differentiation] GO:0030224 [monocyte differentiation] GO:0030324 [lung development] GO:0030851 [granulocyte differentiation] GO:0043353 [enucleate erythrocyte differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0048596 [embryonic camera-type eye morphogenesis] GO:0048706 [embryonic skeletal system development] GO:0060136 [embryonic process involved in female pregnancy] GO:0060216 [definitive hemopoiesis]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding]
