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EGFL7

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GENERAL INFORMATION

Gene name

 EGFL7

Gene description

 EGF-like-domain, multiple 7

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (HUVEC TERT2, TIME, EFO-21)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HUVEC TERT2, TIME, EFO-21)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 EGFL7 (HGNC Symbol)

Synonyms

 ZNEU1

Description

 EGF-like-domain, multiple 7 (HGNC Symbol)

Entrez gene summary

 This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Chromosome

 9

Cytoband

 q34.3

Chromosome location (bp)

 136658856 - 136672678

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172889 (version 83.38)

Entrez gene

 51162

UniProt

 Q9UHF1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHF1

Antibodypedia

 EGFL7 antibodies

PROTEIN BROWSER
EGFL7-001
EGFL7-002
EGFL7-003
EGFL7-005
EGFL7-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EGFL7-001
ENSP00000360764
ENST00000371699
Q9UHF1 [Direct mapping]
Epidermal growth factor-like protein 7
A0A024R8F5 [Target identity:100%; Query identity:100%]
EGF-like-domain, multiple 7, isoform CRA_b
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001568 [blood vessel development]
GO:0001570 [vasculogenesis]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0005112 [Notch binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007155 [cell adhesion]
GO:0030336 [negative regulation of cell migration]
GO:0031012 [extracellular matrix]
GO:0045746 [negative regulation of Notch signaling pathway]
Show all
 273 aa
29.6 kDa 		Yes 0
EGFL7-002
ENSP00000385639
ENST00000406555
Q9UHF1 [Direct mapping]
Epidermal growth factor-like protein 7
A0A024R8F5 [Target identity:100%; Query identity:100%]
EGF-like-domain, multiple 7, isoform CRA_b
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001568 [blood vessel development]
GO:0001570 [vasculogenesis]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007155 [cell adhesion]
GO:0031012 [extracellular matrix]
GO:0045746 [negative regulation of Notch signaling pathway]
Show all
 273 aa
29.6 kDa 		Yes 0
EGFL7-003
ENSP00000360763
ENST00000371698
Q9UHF1 [Direct mapping]
Epidermal growth factor-like protein 7
A0A024R8F5 [Target identity:100%; Query identity:100%]
EGF-like-domain, multiple 7, isoform CRA_b
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001568 [blood vessel development]
GO:0001570 [vasculogenesis]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007155 [cell adhesion]
GO:0031012 [extracellular matrix]
GO:0045746 [negative regulation of Notch signaling pathway]
Show all
 273 aa
29.6 kDa 		Yes 0
EGFL7-005
ENSP00000473338
ENST00000492862
R4GMT3 [Direct mapping]
Epidermal growth factor-like protein 7
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 66 aa
7.4 kDa 		Yes 0
EGFL7-201
ENSP00000307843
ENST00000308874
Q9UHF1 [Direct mapping]
Epidermal growth factor-like protein 7
A0A024R8F5 [Target identity:100%; Query identity:100%]
EGF-like-domain, multiple 7, isoform CRA_b
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001568 [blood vessel development]
GO:0001570 [vasculogenesis]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007155 [cell adhesion]
GO:0031012 [extracellular matrix]
GO:0045746 [negative regulation of Notch signaling pathway]
Show all
 273 aa
29.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.