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NADSYN1

CANCER ATLAS

Gene description

 NAD synthetase 1

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038523
HPA038524
CAB017798

GENE INFORMATION

Gene name

 NADSYN1 (HGNC Symbol)

Synonyms

 FLJ10631

Description

 NAD synthetase 1 (HGNC Symbol)

Entrez gene summary

 Nicotinamide adenine dinucleotide (NAD) is a coenzyme in metabolic redox reactions, a precursor for several cell signaling molecules, and a substrate for protein posttranslational modifications. NAD synthetase (EC 6.3.5.1) catalyzes the final step in the biosynthesis of NAD from nicotinic acid adenine dinucleotide (NaAD).[supplied by OMIM, Apr 2004]

Chromosome

 11

Cytoband

 q13.4

Chromosome location (bp)

 71453109 - 71524107

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172890 (version 83.38)

Entrez gene

 55191

UniProt

 Q6IA69 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6IA69

Antibodypedia

 NADSYN1 antibodies

PROTEIN BROWSER
NADSYN1-001
NADSYN1-004
NADSYN1-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NADSYN1-001
ENSP00000326424
ENST00000319023
Q6IA69 [Direct mapping]
Glutamine-dependent NAD(+) synthetase
Show all
Enzymes
   ENZYME proteins
   Ligase
   THUMBUP predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003952 [NAD+ synthase (glutamine-hydrolyzing) activity]
GO:0004359 [glutaminase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006807 [nitrogen compound metabolic process]
GO:0009435 [NAD biosynthetic process]
GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds]
GO:0019674 [NAD metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 706 aa
79.3 kDa 		No 0
NADSYN1-004
ENSP00000431820
ENST00000530055
A0A0B4J216 [Direct mapping]
Glutamine-dependent NAD(+) synthetase
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003952 [NAD+ synthase (glutamine-hydrolyzing) activity]
GO:0005524 [ATP binding]
GO:0009435 [NAD biosynthetic process]
Show all
 335 aa
37.5 kDa 		No 0
NADSYN1-015
ENSP00000437172
ENST00000529840
E9PNF5 [Direct mapping]
Glutamine-dependent NAD(+) synthetase
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 149 aa
16.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.