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MYD88

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GENERAL INFORMATION

Gene name

 MYD88

Gene description

 Myeloid differentiation primary response 88

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to the mitochondria & vesicles.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (supported)

Additional location

 In addition localized to the Vesicles (approved), Mitochondria (approved)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
CAB009104
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to the mitochondria & vesicles.

Main location

 Cytosol (supported)

Additional location

 Vesicles (approved), Mitochondria (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB009104 A-431 Vesicles
Cytosol
CAB009104 PC-3 No staining    
CAB009104 U-2 OS Mitochondria
Cytosol

GENE INFORMATION

Gene name

 MYD88

Synonyms

Description

 Myeloid differentiation primary response 88 (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Chromosome

 3

Cytoband

 p22.2

Chromosome location (bp)

 38138478 - 38143022

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172936 (version 83.38)

Entrez gene

 4615

UniProt

 Q99836 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99836

Antibodypedia

 MYD88 antibodies

PROTEIN BROWSER
MYD88-001
MYD88-006
MYD88-008
MYD88-009
MYD88-011
MYD88-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYD88-001
ENSP00000379625
ENST00000396334
A0A0A0MS70 [Direct mapping]
Myeloid differentiation primary response protein MyD88
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0070976 [TIR domain binding]
Show all
 309 aa
34.6 kDa 		No 0
MYD88-006
ENSP00000391753
ENST00000421516
H0Y4G9 [Direct mapping]
Myeloid differentiation primary response protein MyD88
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0070976 [TIR domain binding]
Show all
 316 aa
35.3 kDa 		No 0
MYD88-008
ENSP00000417848
ENST00000495303
Q99836 [Direct mapping]
Myeloid differentiation primary response protein MyD88
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0032481 [positive regulation of type I interferon production]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0032747 [positive regulation of interleukin-23 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050727 [regulation of inflammatory response]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070555 [response to interleukin-1]
GO:0070935 [3'-UTR-mediated mRNA stabilization]
GO:0070976 [TIR domain binding]
GO:0071260 [cellular response to mechanical stimulus]
Show all
 159 aa
17.2 kDa 		No 0
MYD88-009
ENSP00000390565
ENST00000443433
Q99836 [Direct mapping]
Myeloid differentiation primary response protein MyD88
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0032481 [positive regulation of type I interferon production]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0032747 [positive regulation of interleukin-23 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050727 [regulation of inflammatory response]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070555 [response to interleukin-1]
GO:0070935 [3'-UTR-mediated mRNA stabilization]
GO:0070976 [TIR domain binding]
GO:0071260 [cellular response to mechanical stimulus]
Show all
 204 aa
22.1 kDa 		No 0
MYD88-011
ENSP00000389979
ENST00000424893
A0A0A0MSI9 [Direct mapping]
Myeloid differentiation primary response protein MyD88
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0070976 [TIR domain binding]
Show all
 264 aa
29.6 kDa 		No 0
MYD88-201
ENSP00000401399
ENST00000417037
A0A0A0MST0 [Direct mapping]
Myeloid differentiation primary response protein MyD88
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002238 [response to molecule of fungal origin]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005102 [receptor binding]
GO:0005121 [Toll binding]
GO:0005149 [interleukin-1 receptor binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007254 [JNK cascade]
GO:0008063 [Toll signaling pathway]
GO:0009615 [response to virus]
GO:0009682 [induced systemic resistance]
GO:0014069 [postsynaptic density]
GO:0016064 [immunoglobulin mediated immune response]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032494 [response to peptidoglycan]
GO:0032496 [response to lipopolysaccharide]
GO:0032675 [regulation of interleukin-6 production]
GO:0032680 [regulation of tumor necrosis factor production]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0032747 [positive regulation of interleukin-23 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0042127 [regulation of cell proliferation]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043234 [protein complex]
GO:0044130 [negative regulation of growth of symbiont in host]
GO:0045080 [positive regulation of chemokine biosynthetic process]
GO:0045351 [type I interferon biosynthetic process]
GO:0046330 [positive regulation of JNK cascade]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050671 [positive regulation of lymphocyte proliferation]
GO:0050727 [regulation of inflammatory response]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0070976 [TIR domain binding]
GO:0090557 [establishment of endothelial intestinal barrier]
GO:1902622 [regulation of neutrophil migration]
GO:2000338 [regulation of chemokine (C-X-C motif) ligand 1 production]
GO:2000341 [regulation of chemokine (C-X-C motif) ligand 2 production]
Show all
 317 aa
35.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.