Cell atlas - OXSR1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	OXSR1
Gene description	Oxidative stress responsive 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (validated)
siRNA	The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA008237
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ASSAYS

RNA expression

Human cells

siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA008237	A-431	Cytosol
HPA008237	U-2 OS	Cytosol
HPA008237	U-251 MG	Cytosol

siRNA VALIDATION

Relative fluorescence intensity (RFI)

Antibody

HPA008237

siRNA validation

Validated: Significant downregulation > 25% by both siRNA:s.

Analysis performed in

Whole cells of segmented cells in 10x-images

siRNA 1

siRNA 2

RFI

59%

54%

p-value

< 0.01


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Sample	Cell line
HPA008237	siRNA 1	U-2 OS
HPA008237	siRNA 2	U-2 OS
HPA008237	scrambled	U-2 OS

GENE INFORMATION
Gene name	OXSR1 (HGNC Symbol)
Synonyms	KIAA1101, OSR1
Description	Oxidative stress responsive 1 (HGNC Symbol)
Entrez gene summary	The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p22.2
Chromosome location (bp)	38165089 - 38255488
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172939 (version 83.38)
Entrez gene	9943
UniProt	O95747 (UniProt - Evidence at protein level)
neXtProt	NX_O95747
Antibodypedia	OXSR1 antibodies

PROTEIN BROWSER

OXSR1-001	OXSR1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OXSR1-001 ENSP00000311713 ENST00000311806	O95747 [Direct mapping] Serine/threonine-protein kinase OSR1 A0A024R2M7 [Target identity:100%; Query identity:100%] Oxidative-stress responsive 1, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0006979 [response to oxidative stress] GO:0007346 [regulation of mitotic cell cycle] GO:0018107 [peptidyl-threonine phosphorylation] GO:0023014 [signal transduction by protein phosphorylation] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0032147 [activation of protein kinase activity] GO:0035556 [intracellular signal transduction] GO:0042981 [regulation of apoptotic process] GO:0070062 [extracellular exosome] GO:0071476 [cellular hypotonic response] GO:1901017 [negative regulation of potassium ion transmembrane transporter activity] GO:1901380 [negative regulation of potassium ion transmembrane transport] GO:2000681 [negative regulation of rubidium ion transport] GO:2000687 [negative regulation of rubidium ion transmembrane transporter activity] Show all	527 aa 58 kDa	No	0
OXSR1-004 ENSP00000415851 ENST00000446845	C9JIG9 [Direct mapping] Serine/threonine-protein kinase OSR1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007346 [regulation of mitotic cell cycle] GO:0023014 [signal transduction by protein phosphorylation] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0032147 [activation of protein kinase activity] GO:0042981 [regulation of apoptotic process] Show all	468 aa 51.9 kDa	No	0