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PHF8

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GENERAL INFORMATION

Gene name

 PHF8

Gene description

 PHD finger protein 8

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 14
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA062015
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus.

Main location

 Nucleus (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA062015 HEK 293 Nucleus
Nuclear membrane
HPA062015 SiHa Nucleus
HPA062015 U-2 OS Nucleus

GENE INFORMATION

Gene name

 PHF8 (HGNC Symbol)

Synonyms

 JHDM1F, KIAA1111, ZNF422

Description

 PHD finger protein 8 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. Defects in this gene are a cause of mental retardation syndromic X-linked Siderius type (MRXSSD). Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

Chromosome

 X

Cytoband

 p11.22

Chromosome location (bp)

 53936676 - 54048958

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172943 (version 83.38)

Entrez gene

 23133

UniProt

 Q9UPP1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UPP1

Antibodypedia

 PHF8 antibodies

PROTEIN BROWSER
«
PHF8-001
PHF8-002
PHF8-003
PHF8-004
PHF8-006
PHF8-007
PHF8-010
PHF8-011
PHF8-012
PHF8-013
PHF8-014
PHF8-016
PHF8-201
PHF8-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PHF8-001
ENSP00000350676
ENST00000357988
Q9UPP1 [Direct mapping]
Histone lysine demethylase PHF8
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003682 [chromatin binding]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0007420 [brain development]
GO:0008270 [zinc ion binding]
GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors]
GO:0031965 [nuclear membrane]
GO:0032452 [histone demethylase activity]
GO:0032454 [histone demethylase activity (H3-K9 specific)]
GO:0033169 [histone H3-K9 demethylation]
GO:0035064 [methylated histone binding]
GO:0035574 [histone H4-K20 demethylation]
GO:0035575 [histone demethylase activity (H4-K20 specific)]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045943 [positive regulation of transcription from RNA polymerase I promoter]
GO:0051864 [histone demethylase activity (H3-K36 specific)]
GO:0055114 [oxidation-reduction process]
GO:0061188 [negative regulation of chromatin silencing at rDNA]
GO:0070544 [histone H3-K36 demethylation]
GO:0071557 [histone H3-K27 demethylation]
GO:0071558 [histone demethylase activity (H3-K27 specific)]
Show all
 1060 aa
117.9 kDa 		No 0
PHF8-002
ENSP00000319473
ENST00000322659
Q9UPP1 [Direct mapping]
Histone lysine demethylase PHF8
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003682 [chromatin binding]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0007420 [brain development]
GO:0008270 [zinc ion binding]
GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors]
GO:0031965 [nuclear membrane]
GO:0032452 [histone demethylase activity]
GO:0032454 [histone demethylase activity (H3-K9 specific)]
GO:0033169 [histone H3-K9 demethylation]
GO:0035064 [methylated histone binding]
GO:0035574 [histone H4-K20 demethylation]
GO:0035575 [histone demethylase activity (H4-K20 specific)]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045943 [positive regulation of transcription from RNA polymerase I promoter]
GO:0051864 [histone demethylase activity (H3-K36 specific)]
GO:0055114 [oxidation-reduction process]
GO:0061188 [negative regulation of chromatin silencing at rDNA]
GO:0070544 [histone H3-K36 demethylation]
GO:0071557 [histone H3-K27 demethylation]
GO:0071558 [histone demethylase activity (H3-K27 specific)]
Show all
 878 aa
98.3 kDa 		No 0
PHF8-003
ENSP00000338868
ENST00000338154
Q9UPP1 [Direct mapping]
Histone lysine demethylase PHF8
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003682 [chromatin binding]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0007420 [brain development]
GO:0008270 [zinc ion binding]
GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors]
GO:0031965 [nuclear membrane]
GO:0032452 [histone demethylase activity]
GO:0032454 [histone demethylase activity (H3-K9 specific)]
GO:0033169 [histone H3-K9 demethylation]
GO:0035064 [methylated histone binding]
GO:0035574 [histone H4-K20 demethylation]
GO:0035575 [histone demethylase activity (H4-K20 specific)]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045943 [positive regulation of transcription from RNA polymerase I promoter]
GO:0051864 [histone demethylase activity (H3-K36 specific)]
GO:0055114 [oxidation-reduction process]
GO:0061188 [negative regulation of chromatin silencing at rDNA]
GO:0070544 [histone H3-K36 demethylation]
GO:0071557 [histone H3-K27 demethylation]
GO:0071558 [histone demethylase activity (H3-K27 specific)]
Show all
 1024 aa
113.9 kDa 		No 0
PHF8-004
ENSP00000404117
ENST00000415025
Q5JPR8 [Direct mapping]
Histone lysine demethylase PHF8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
Show all
 114 aa
12.8 kDa 		No 0
PHF8-006
ENSP00000397129
ENST00000443302
H0Y589 [Direct mapping]
Histone lysine demethylase PHF8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 659 aa
72.8 kDa 		No 0
PHF8-007
ENSP00000379578
ENST00000396282
H0Y3N9 [Direct mapping]
Histone lysine demethylase PHF8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 953 aa
105.9 kDa 		No 0
PHF8-010
ENSP00000405897
ENST00000453905
B0QZE1 [Direct mapping]
Histone lysine demethylase PHF8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
Show all
 148 aa
16.6 kDa 		No 0
PHF8-011
ENSP00000398995
ENST00000437224
B0QZZ2 [Direct mapping]
Histone lysine demethylase PHF8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
Show all
 115 aa
13 kDa 		No 0
PHF8-012
ENSP00000416546
ENST00000445025
B0QZZ4 [Direct mapping]
Histone lysine demethylase PHF8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
Show all
 97 aa
11 kDa 		No 0
PHF8-013
ENSP00000410100
ENST00000433120
B0QZZ4 [Direct mapping]
Histone lysine demethylase PHF8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
Show all
 97 aa
11 kDa 		No 0
PHF8-014
ENSP00000408113
ENST00000425862
B0QZZ3 [Direct mapping]
Histone lysine demethylase PHF8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
Show all
 126 aa
14.2 kDa 		No 0
PHF8-016
ENSP00000414028
ENST00000448003
H0Y7M8 [Direct mapping]
Histone lysine demethylase PHF8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 134 aa
15.4 kDa 		No 0
PHF8-201
ENSP00000340051
ENST00000338946
Q9UPP1 [Direct mapping]
Histone lysine demethylase PHF8
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003682 [chromatin binding]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0007420 [brain development]
GO:0008270 [zinc ion binding]
GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors]
GO:0031965 [nuclear membrane]
GO:0032452 [histone demethylase activity]
GO:0032454 [histone demethylase activity (H3-K9 specific)]
GO:0033169 [histone H3-K9 demethylation]
GO:0035064 [methylated histone binding]
GO:0035574 [histone H4-K20 demethylation]
GO:0035575 [histone demethylase activity (H4-K20 specific)]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045943 [positive regulation of transcription from RNA polymerase I promoter]
GO:0051864 [histone demethylase activity (H3-K36 specific)]
GO:0055114 [oxidation-reduction process]
GO:0061188 [negative regulation of chromatin silencing at rDNA]
GO:0070544 [histone H3-K36 demethylation]
GO:0071557 [histone H3-K27 demethylation]
GO:0071558 [histone demethylase activity (H3-K27 specific)]
Show all
 948 aa
105.9 kDa 		No 0
PHF8-202
ENSP00000482159
ENST00000615775
A0A087WYX2 [Direct mapping]
Histone lysine demethylase PHF8
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 303 aa
33.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.