Tissue expression of ADH6 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ADH6
Gene description	Alcohol dehydrogenase 6 (class V)
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (liver)
GTEx:	Tissue enriched (liver)
FANTOM5:	Group enriched (liver, small intestine)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (liver, small intestine)

GENE INFORMATION
Gene name	ADH6 (HGNC Symbol)
Synonyms	ADH-5
Description	Alcohol dehydrogenase 6 (class V) (HGNC Symbol)
Entrez gene summary	This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5' UTR, which is a steroid hormone receptor binding site. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q23
Chromosome location (bp)	99202638 - 99219537
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172955 (version 83.38)
Entrez gene	130
UniProt	P28332 (UniProt - Evidence at protein level)
neXtProt	NX_P28332
Antibodypedia	ADH6 antibodies

PROTEIN BROWSER

ADH6-001	ADH6-002	ADH6-003	ADH6-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADH6-001 ENSP00000378359 ENST00000394899	A0A0A0MS56 [Direct mapping] Alcohol dehydrogenase 6 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	375 aa 39.8 kDa	No	0
ADH6-002 ENSP00000378358 ENST00000394897	Q8IUN7 [Direct mapping] ADH6 protein; Alcohol dehydrogenase 6 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	295 aa 31.3 kDa	No	0
ADH6-003 ENSP00000237653 ENST00000237653	P28332 [Direct mapping] Alcohol dehydrogenase 6 Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004022 [alcohol dehydrogenase (NAD) activity] GO:0005829 [cytosol] GO:0006069 [ethanol oxidation] GO:0006805 [xenobiotic metabolic process] GO:0008270 [zinc ion binding] GO:0016491 [oxidoreductase activity] GO:0044281 [small molecule metabolic process] GO:0045471 [response to ethanol] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	368 aa 39.1 kDa	No	0
ADH6-008 ENSP00000426187 ENST00000508558	D6RH17 [Direct mapping] Alcohol dehydrogenase 6 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	257 aa 26.5 kDa	No	0