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KAT5

CANCER ATLAS

Gene description

 K(lysine) acetyltransferase 5

Protein class

 Enzymes, Predicted intracellular proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA016953

GENE INFORMATION

Gene name

 KAT5 (HGNC Symbol)

Synonyms

 cPLA2, ESA1, HTATIP, HTATIP1, PLIP, TIP60, ZC2HC5

Description

 K(lysine) acetyltransferase 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 65711996 - 65719604

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172977 (version 83.38)

Entrez gene

 10524

UniProt

 Q92993 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92993

Antibodypedia

 KAT5 antibodies

PROTEIN BROWSER
«
KAT5-001
KAT5-002
KAT5-003
KAT5-004
KAT5-005
KAT5-009
KAT5-013
KAT5-014
KAT5-015
KAT5-016
KAT5-018
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KAT5-001
ENSP00000340330
ENST00000341318
Q92993 [Direct mapping]
Histone acetyltransferase KAT5
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000812 [Swr1 complex]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0010212 [response to ionizing radiation]
GO:0016032 [viral process]
GO:0016407 [acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0030521 [androgen receptor signaling pathway]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0032777 [Piccolo NuA4 histone acetyltransferase complex]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0040008 [regulation of growth]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050681 [androgen receptor binding]
GO:0070491 [repressing transcription factor binding]
GO:0071392 [cellular response to estradiol stimulus]
GO:1901985 [positive regulation of protein acetylation]
Show all
 546 aa
61.8 kDa 		No 0
KAT5-002
ENSP00000366245
ENST00000377046
Q92993 [Direct mapping]
Histone acetyltransferase KAT5
A0A024R597 [Target identity:100%; Query identity:100%]
Histone acetyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000812 [Swr1 complex]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0010212 [response to ionizing radiation]
GO:0016032 [viral process]
GO:0016407 [acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0030521 [androgen receptor signaling pathway]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0032777 [Piccolo NuA4 histone acetyltransferase complex]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0040008 [regulation of growth]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050681 [androgen receptor binding]
GO:0070491 [repressing transcription factor binding]
GO:0071392 [cellular response to estradiol stimulus]
GO:1901985 [positive regulation of protein acetylation]
Show all
 513 aa
58.6 kDa 		No 0
KAT5-003
ENSP00000344955
ENST00000352980
Q92993 [Direct mapping]
Histone acetyltransferase KAT5
A0A024R5E8 [Target identity:100%; Query identity:100%]
Histone acetyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000812 [Swr1 complex]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0010212 [response to ionizing radiation]
GO:0016032 [viral process]
GO:0016407 [acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0030521 [androgen receptor signaling pathway]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0032777 [Piccolo NuA4 histone acetyltransferase complex]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0040008 [regulation of growth]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050681 [androgen receptor binding]
GO:0070491 [repressing transcription factor binding]
GO:0071392 [cellular response to estradiol stimulus]
GO:1901985 [positive regulation of protein acetylation]
Show all
 461 aa
53.1 kDa 		No 0
KAT5-004
ENSP00000434765
ENST00000530446
Q92993 [Direct mapping]
Histone acetyltransferase KAT5
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000812 [Swr1 complex]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0010212 [response to ionizing radiation]
GO:0016032 [viral process]
GO:0016407 [acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0030521 [androgen receptor signaling pathway]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0032777 [Piccolo NuA4 histone acetyltransferase complex]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0040008 [regulation of growth]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050681 [androgen receptor binding]
GO:0070491 [repressing transcription factor binding]
GO:0071392 [cellular response to estradiol stimulus]
GO:1901985 [positive regulation of protein acetylation]
Show all
 494 aa
56.3 kDa 		No 0
KAT5-005
ENSP00000431819
ENST00000534650
E9PJI1 [Direct mapping]
Histone acetyltransferase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004402 [histone acetyltransferase activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016573 [histone acetylation]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
Show all
 302 aa
35.4 kDa 		No 0
KAT5-009
ENSP00000435766
ENST00000533596
H0YEG3 [Direct mapping]
Histone acetyltransferase KAT5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008152 [metabolic process]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
Show all
 95 aa
10.9 kDa 		No 0
KAT5-013
ENSP00000434993
ENST00000534681
E9PMG8 [Direct mapping]
Histone acetyltransferase KAT5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008152 [metabolic process]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
Show all
 45 aa
5.3 kDa 		No 0
KAT5-014
ENSP00000435939
ENST00000534104
E9PRS1 [Direct mapping]
Histone acetyltransferase KAT5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 16 aa
1.7 kDa 		No 0
KAT5-015
ENSP00000436000
ENST00000528198
E9PRM3 [Direct mapping]
Histone acetyltransferase KAT5
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 189 aa
21.3 kDa 		No 0
KAT5-016
ENSP00000436012
ENST00000531880
E9PRL6 [Direct mapping]
Histone acetyltransferase KAT5
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008152 [metabolic process]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
Show all
 269 aa
30 kDa 		No 0
KAT5-018
ENSP00000436247
ENST00000530605
H0YEP0 [Direct mapping]
Histone acetyltransferase KAT5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 167 aa
18.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.