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A majority of cancers displayed moderate granular cytoplasmic immunoreactivity. A few cases of urothelial, liver and renal cancers were strongly stained. Several cases of cervical, lung and skin cancers were weakly stained or negative.
COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).[supplied by OMIM, Sep 2009]