Cell atlas - RAPH1 - The Human Protein Atlas

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RAPH1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear bodies
	Plasma membrane

Human cell
	Cytosol
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	RAPH1
Gene description	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane & nuclear bodies. In addition localized to the cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear bodies (uncertain), Plasma membrane (supported)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA020027
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane & nuclear bodies. In addition localized to the cytosol.

Main location

Nuclear bodies (uncertain), Plasma membrane (supported)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA020027	A-431	Nuclear bodies
	HPA020027	A-431	Cytosol
	HPA020027	U-2 OS	Nuclear bodies
			Plasma membrane
			Cytosol
	HPA020027	U-251 MG	Nuclear bodies
			Plasma membrane
			Cytosol

GENE INFORMATION
Gene name	RAPH1 (HGNC Symbol)
Synonyms	ALS2CR18, ALS2CR9, KIAA1681
Description	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q33.2
Chromosome location (bp)	203394345 - 203535410
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173166 (version 83.38)
Entrez gene	65059
UniProt	Q70E73 (UniProt - Evidence at protein level)
neXtProt	NX_Q70E73
Antibodypedia	RAPH1 antibodies

PROTEIN BROWSER

RAPH1-001	RAPH1-002	RAPH1-004	RAPH1-005	RAPH1-007	RAPH1-009	RAPH1-011	RAPH1-013	RAPH1-014	RAPH1-015	RAPH1-017	RAPH1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RAPH1-001 ENSP00000316543 ENST00000319170	Q70E73 [Direct mapping] Ras-associated and pleckstrin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0007160 [cell-matrix adhesion] GO:0007165 [signal transduction] GO:0030027 [lamellipodium] GO:0030175 [filopodium] GO:0031252 [cell leading edge] GO:0048675 [axon extension] Show all	1250 aa 135.3 kDa	No	0
RAPH1-002 ENSP00000311293 ENST00000308091	Q70E73 [Direct mapping] Ras-associated and pleckstrin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0007160 [cell-matrix adhesion] GO:0007165 [signal transduction] GO:0030027 [lamellipodium] GO:0030175 [filopodium] Show all	644 aa 72.9 kDa	No	0
RAPH1-004 ENSP00000406662 ENST00000453034	Q70E73 [Direct mapping] Ras-associated and pleckstrin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0007160 [cell-matrix adhesion] GO:0007165 [signal transduction] GO:0030027 [lamellipodium] GO:0030175 [filopodium] Show all	649 aa 73.4 kDa	No	0
RAPH1-005 ENSP00000392854 ENST00000457812	C9J164 [Direct mapping] Ras-associated and pleckstrin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007165 [signal transduction] Show all	594 aa 67.2 kDa	No	0
RAPH1-007 ENSP00000414430 ENST00000428637	C9JLG4 [Direct mapping] Ras-associated and pleckstrin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		172 aa 19.1 kDa	No	0
RAPH1-009 ENSP00000412241 ENST00000420371	C9J0R8 [Direct mapping] Ras-associated and pleckstrin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		89 aa 10.2 kDa	No	0
RAPH1-011 ENSP00000411138 ENST00000439222	Q70E73 [Direct mapping] Ras-associated and pleckstrin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0007160 [cell-matrix adhesion] GO:0007165 [signal transduction] GO:0030027 [lamellipodium] GO:0030175 [filopodium] Show all	617 aa 69.8 kDa	No	0
RAPH1-013 ENSP00000390578 ENST00000419464	Q70E73 [Direct mapping] Ras-associated and pleckstrin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0007160 [cell-matrix adhesion] GO:0007165 [signal transduction] GO:0030027 [lamellipodium] GO:0030175 [filopodium] Show all	592 aa 66.9 kDa	No	0
RAPH1-014 ENSP00000396711 ENST00000418114	Q70E73 [Direct mapping] Ras-associated and pleckstrin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0007160 [cell-matrix adhesion] GO:0007165 [signal transduction] GO:0030027 [lamellipodium] GO:0030175 [filopodium] Show all	597 aa 67.5 kDa	No	0
RAPH1-015 ENSP00000397751 ENST00000423104	Q70E73 [Direct mapping] Ras-associated and pleckstrin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0007160 [cell-matrix adhesion] GO:0007165 [signal transduction] GO:0030027 [lamellipodium] GO:0030175 [filopodium] Show all	619 aa 70 kDa	No	0
RAPH1-017 ENSP00000363617 ENST00000374493	C9K0J5 [Direct mapping] Ras association (RalGDS/AF-6) and pleckstrin homology domains 1, isoform CRA_b; Ras-associated and pleckstrin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005856 [cytoskeleton] GO:0007160 [cell-matrix adhesion] GO:0007165 [signal transduction] Show all	1302 aa 141.2 kDa	No	0
RAPH1-201 ENSP00000486548 ENST00000630330	C9K0J5 [Direct mapping] Ras association (RalGDS/AF-6) and pleckstrin homology domains 1, isoform CRA_b; Ras-associated and pleckstrin homology domains-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005856 [cytoskeleton] GO:0007160 [cell-matrix adhesion] GO:0007165 [signal transduction] Show all	1302 aa 141.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.