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GLRX

GENERAL INFORMATION

Gene name

 GLRX

Gene description

 Glutaredoxin (thioltransferase)

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, including kidney, gastrointestinal tract and placenta.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA046431 , CAB008634 , CAB069419
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GLRX (HGNC Symbol)

Synonyms

 GRX, GRX1

Description

 Glutaredoxin (thioltransferase) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]

Chromosome

 5

Cytoband

 q15

Chromosome location (bp)

 95751319 - 95823005

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173221 (version 83.38)

Entrez gene

 2745

UniProt

 P35754 (UniProt - Evidence at protein level)

neXtProt

 NX_P35754

Antibodypedia

 GLRX antibodies

PROTEIN BROWSER
GLRX-001
GLRX-002
GLRX-004
GLRX-005
GLRX-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GLRX-001
ENSP00000237858
ENST00000237858
P35754 [Direct mapping]
Glutaredoxin-1
A0A024RAM2 [Target identity:100%; Query identity:100%]
Glutaredoxin (Thioltransferase), isoform CRA_c
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0009055 [electron carrier activity]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0015038 [glutathione disulfide oxidoreductase activity]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0044281 [small molecule metabolic process]
GO:0045454 [cell redox homeostasis]
GO:0045838 [positive regulation of membrane potential]
GO:0047485 [protein N-terminus binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0080058 [protein deglutathionylation]
GO:0097573 [glutathione oxidoreductase activity]
GO:2000651 [positive regulation of sodium ion transmembrane transporter activity]
Show all
 106 aa
11.8 kDa 		No 0
GLRX-002
ENSP00000369314
ENST00000379979
P35754 [Direct mapping]
Glutaredoxin-1
A0A024RAM2 [Target identity:100%; Query identity:100%]
Glutaredoxin (Thioltransferase), isoform CRA_c
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0009055 [electron carrier activity]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0015038 [glutathione disulfide oxidoreductase activity]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0044281 [small molecule metabolic process]
GO:0045454 [cell redox homeostasis]
GO:0045838 [positive regulation of membrane potential]
GO:0047485 [protein N-terminus binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0080058 [protein deglutathionylation]
GO:0097573 [glutathione oxidoreductase activity]
GO:2000651 [positive regulation of sodium ion transmembrane transporter activity]
Show all
 106 aa
11.8 kDa 		No 0
GLRX-004
ENSP00000427353
ENST00000505427
P35754 [Direct mapping]
Glutaredoxin-1
A0A024RAM2 [Target identity:100%; Query identity:100%]
Glutaredoxin (Thioltransferase), isoform CRA_c
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0009055 [electron carrier activity]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0015038 [glutathione disulfide oxidoreductase activity]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0044281 [small molecule metabolic process]
GO:0045454 [cell redox homeostasis]
GO:0045838 [positive regulation of membrane potential]
GO:0047485 [protein N-terminus binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0080058 [protein deglutathionylation]
GO:0097573 [glutathione oxidoreductase activity]
GO:2000651 [positive regulation of sodium ion transmembrane transporter activity]
Show all
 106 aa
11.8 kDa 		No 0
GLRX-005
ENSP00000424636
ENST00000512469
P35754 [Direct mapping]
Glutaredoxin-1
A0A024RAM2 [Target identity:100%; Query identity:100%]
Glutaredoxin (Thioltransferase), isoform CRA_c
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0009055 [electron carrier activity]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0015038 [glutathione disulfide oxidoreductase activity]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0044281 [small molecule metabolic process]
GO:0045454 [cell redox homeostasis]
GO:0045838 [positive regulation of membrane potential]
GO:0047485 [protein N-terminus binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0080058 [protein deglutathionylation]
GO:0097573 [glutathione oxidoreductase activity]
GO:2000651 [positive regulation of sodium ion transmembrane transporter activity]
Show all
 106 aa
11.8 kDa 		No 0
GLRX-007
ENSP00000422708
ENST00000508780
P35754 [Direct mapping]
Glutaredoxin-1
A0A024RAM2 [Target identity:100%; Query identity:100%]
Glutaredoxin (Thioltransferase), isoform CRA_c
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0009055 [electron carrier activity]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0015038 [glutathione disulfide oxidoreductase activity]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0044281 [small molecule metabolic process]
GO:0045454 [cell redox homeostasis]
GO:0045838 [positive regulation of membrane potential]
GO:0047485 [protein N-terminus binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0080058 [protein deglutathionylation]
GO:0097573 [glutathione oxidoreductase activity]
GO:2000651 [positive regulation of sodium ion transmembrane transporter activity]
Show all
 106 aa
11.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.