Cell atlas - SLC2A14 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SLC2A14
Gene description	Solute carrier family 2 (facilitated glucose transporter), member 14
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	18
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (CACO-2, BEWO)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA006539
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CACO-2, BEWO) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA006539	CACO-2	Plasma membrane
HPA006539	Hep G2	Plasma membrane
HPA006539	Hep G2	Aggresome
HPA006539	U-2 OS	Plasma membrane

GENE INFORMATION
Gene name	SLC2A14 (HGNC Symbol)
Synonyms	GLUT14, SLC2A3P3
Description	Solute carrier family 2 (facilitated glucose transporter), member 14 (HGNC Symbol)
Entrez gene summary	Members of the glucose transporter (GLUT) family, including SLC2A14, are highly conserved integral membrane proteins that transport hexoses such as glucose and fructose into all mammalian cells. GLUTs show tissue and cell-type specific expression (Wu and Freeze, 2002 [PubMed 12504846]).[supplied by OMIM, Mar 2008]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	7812512 - 7891148
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173262 (version 83.38)
Entrez gene	144195
UniProt	Q8TDB8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8TDB8
Antibodypedia	SLC2A14 antibodies

PROTEIN BROWSER

SLC2A14-001	SLC2A14-002	SLC2A14-003	SLC2A14-004	SLC2A14-005	SLC2A14-006	SLC2A14-007	SLC2A14-008	SLC2A14-009	SLC2A14-010	SLC2A14-011	SLC2A14-012	SLC2A14-015	SLC2A14-016	SLC2A14-017	SLC2A14-018	SLC2A14-201	SLC2A14-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC2A14-001 ENSP00000440480 ENST00000543909	Q8TDB8 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 14 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005634 [nucleus] GO:0005887 [integral component of plasma membrane] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0030154 [cell differentiation] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] GO:1904659 [glucose transmembrane transport] Show all	520 aa 56.3 kDa	No	>9
SLC2A14-002 ENSP00000379834 ENST00000396589	Q8TDB8 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 14 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005634 [nucleus] GO:0005887 [integral component of plasma membrane] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0030154 [cell differentiation] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] GO:1904659 [glucose transmembrane transport] Show all	520 aa 56.3 kDa	No	>9
SLC2A14-003 ENSP00000445929 ENST00000539924	Q8TDB8 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 14 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005634 [nucleus] GO:0005887 [integral component of plasma membrane] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0030154 [cell differentiation] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] GO:1904659 [glucose transmembrane transport] Show all	535 aa 58.2 kDa	No	>9
SLC2A14-004 ENSP00000438484 ENST00000542505	Q8TDB8 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 14 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005634 [nucleus] GO:0005887 [integral component of plasma membrane] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0030154 [cell differentiation] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] GO:1904659 [glucose transmembrane transport] Show all	161 aa 17.4 kDa	No	2
SLC2A14-005 ENSP00000407287 ENST00000431042	Q8TDB8 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 14 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005634 [nucleus] GO:0005887 [integral component of plasma membrane] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0030154 [cell differentiation] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] GO:1904659 [glucose transmembrane transport] Show all	497 aa 54 kDa	No	>9
SLC2A14-006 ENSP00000340450 ENST00000340749	Q8TDB8 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 14 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005634 [nucleus] GO:0005887 [integral component of plasma membrane] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0030154 [cell differentiation] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] GO:1904659 [glucose transmembrane transport] Show all	497 aa 54 kDa	No	>9
SLC2A14-007 ENSP00000440492 ENST00000535295	Q8TDB8 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 14 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005634 [nucleus] GO:0005887 [integral component of plasma membrane] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0030154 [cell differentiation] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] GO:1904659 [glucose transmembrane transport] Show all	411 aa 44.9 kDa	No	8
SLC2A14-008 ENSP00000443076 ENST00000535383	F5H5V7 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005887 [integral component of plasma membrane] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] GO:1904659 [glucose transmembrane transport] Show all	47 aa 5.2 kDa	No	1
SLC2A14-009 ENSP00000437653 ENST00000535266	F5H6F6 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005887 [integral component of plasma membrane] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] GO:1904659 [glucose transmembrane transport] Show all	120 aa 12.8 kDa	No	1
SLC2A14-010 ENSP00000438312 ENST00000542782	F5H076 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005887 [integral component of plasma membrane] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] GO:1904659 [glucose transmembrane transport] Show all	152 aa 16.2 kDa	No	4
SLC2A14-011 ENSP00000440044 ENST00000537557	F5GXP7 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005887 [integral component of plasma membrane] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] GO:1904659 [glucose transmembrane transport] Show all	141 aa 14.9 kDa	No	2
SLC2A14-012 ENSP00000440043 ENST00000546234	F5GXP8 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005887 [integral component of plasma membrane] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] GO:1904659 [glucose transmembrane transport] Show all	169 aa 17.9 kDa	No	4
SLC2A14-015 ENSP00000444692 ENST00000539234	F5H565 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 14 Show all	Predicted intracellular proteins Show all	GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005887 [integral component of plasma membrane] GO:0015992 [proton transport] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:1904659 [glucose transmembrane transport] Show all	13 aa 1.7 kDa	No	0
SLC2A14-016 ENSP00000443217 ENST00000535344	F5H5Q3 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005887 [integral component of plasma membrane] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] GO:1904659 [glucose transmembrane transport] Show all	141 aa 15 kDa	No	4
SLC2A14-017 ENSP00000442402 ENST00000542916	F5H7N2 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005887 [integral component of plasma membrane] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] GO:1904659 [glucose transmembrane transport] Show all	84 aa 8.9 kDa	No	1
SLC2A14-018 ENSP00000438876 ENST00000535587	F5H3J0 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 14 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005887 [integral component of plasma membrane] GO:0015992 [proton transport] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:1904659 [glucose transmembrane transport] Show all	22 aa 2.3 kDa	No	0
SLC2A14-201 ENSP00000443903 ENST00000542546	Q8TDB8 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 14 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005634 [nucleus] GO:0005887 [integral component of plasma membrane] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0030154 [cell differentiation] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] GO:1904659 [glucose transmembrane transport] Show all	411 aa 44.9 kDa	No	8
SLC2A14-202 ENSP00000482927 ENST00000616981	Q8TDB8 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 14 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005634 [nucleus] GO:0005887 [integral component of plasma membrane] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0030154 [cell differentiation] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] GO:1904659 [glucose transmembrane transport] Show all	520 aa 56.3 kDa	No	>9