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MAP3K11

CANCER ATLAS

Gene description

 Mitogen-activated protein kinase kinase kinase 11

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB010165

GENE INFORMATION

Gene name

 MAP3K11 (HGNC Symbol)

Synonyms

 MEKK11, MLK3, PTK1, SPRK

Description

 Mitogen-activated protein kinase kinase kinase 11 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 65597755 - 65615382

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173327 (version 83.38)

Entrez gene

 4296

UniProt

 Q16584 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16584

Antibodypedia

 MAP3K11 antibodies

PROTEIN BROWSER
MAP3K11-001
MAP3K11-004
MAP3K11-006
MAP3K11-012
MAP3K11-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAP3K11-001
ENSP00000309597
ENST00000309100
Q16584 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 11
A0A024R5E6 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase kinase kinase 11, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004706 [JUN kinase kinase kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005874 [microtubule]
GO:0006468 [protein phosphorylation]
GO:0007017 [microtubule-based process]
GO:0007254 [JNK cascade]
GO:0007256 [activation of JNKK activity]
GO:0007257 [activation of JUN kinase activity]
GO:0008219 [cell death]
GO:0008283 [cell proliferation]
GO:0016020 [membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0048365 [Rac GTPase binding]
Show all
 847 aa
92.7 kDa 		No 0
MAP3K11-004
ENSP00000433886
ENST00000530153
Q16584 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 11
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004706 [JUN kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005874 [microtubule]
GO:0006468 [protein phosphorylation]
GO:0007017 [microtubule-based process]
GO:0007254 [JNK cascade]
GO:0007257 [activation of JUN kinase activity]
GO:0008283 [cell proliferation]
GO:0016020 [membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
Show all
 590 aa
65.3 kDa 		No 0
MAP3K11-006
ENSP00000432068
ENST00000532507
E9PID4 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 11
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 263 aa
27.6 kDa 		No 0
MAP3K11-012
ENSP00000435970
ENST00000526293
E9PRQ2 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 11
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 111 aa
12.3 kDa 		No 0
MAP3K11-013
ENSP00000435237
ENST00000529839
E9PLB1 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 11
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 97 aa
10.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.