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XCR1

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GENERAL INFORMATION

Gene name

 XCR1

Gene description

 Chemokine (C motif) receptor 1

Protein class

 G-protein coupled receptors
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (Karpas-707)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Karpas-707)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 XCR1 (HGNC Symbol)

Synonyms

 CCXCR1, GPR5

Description

 Chemokine (C motif) receptor 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 46017024 - 46027742

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173578 (version 83.38)

Entrez gene

 2829

UniProt

 P46094 (UniProt - Evidence at protein level)

neXtProt

 NX_P46094

Antibodypedia

 XCR1 antibodies

PROTEIN BROWSER
XCR1-001
XCR1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
XCR1-001
ENSP00000310405
ENST00000309285
P46094 [Direct mapping]
Chemokine XC receptor 1
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G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0016021 [integral component of membrane]
GO:0034097 [response to cytokine]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
 333 aa
38.5 kDa 		No 7
XCR1-002
ENSP00000379277
ENST00000395946
Q689E2 [Direct mapping]
Chemokine C motif receptor 1; Chemokine XC receptor 1
Show all
Predicted intracellular proteins
Show all
 36 aa
4.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.