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SCAI

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GENERAL INFORMATION

Gene name

 SCAI

Gene description

 Suppressor of cancer cell invasion

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus & nuclear membrane.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported), Nuclear membrane (approved)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA020632
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus & nuclear membrane.

Main location

 Nucleus (supported), Nuclear membrane (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA020632 A-431 Nucleus
Nuclear membrane
HPA020632 U-2 OS Nucleus
Nuclear membrane
HPA020632 U-251 MG Nucleus
Nuclear membrane

GENE INFORMATION

Gene name

 SCAI (HGNC Symbol)

Synonyms

 C9orf126, FLJ36664, NET40

Description

 Suppressor of cancer cell invasion (HGNC Symbol)

Entrez gene summary

 This gene encodes a regulator of cell migration. The encoded protein appears to function in the RhoA (ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]

Chromosome

 9

Cytoband

 q33.3

Chromosome location (bp)

 124942608 - 125143506

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173611 (version 83.38)

Entrez gene

 286205

UniProt

 Q8N9R8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N9R8

Antibodypedia

 SCAI antibodies

PROTEIN BROWSER
SCAI-001
SCAI-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SCAI-001
ENSP00000336756
ENST00000336505
Q8N9R8 [Direct mapping]
Protein SCAI
Show all
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016021 [integral component of membrane]
GO:0030336 [negative regulation of cell migration]
GO:0031965 [nuclear membrane]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 606 aa
70.4 kDa 		No 0
SCAI-003
ENSP00000362650
ENST00000373549
Q8N9R8 [Direct mapping]
Protein SCAI
Show all
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016021 [integral component of membrane]
GO:0030336 [negative regulation of cell migration]
GO:0031965 [nuclear membrane]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 629 aa
72.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.