Tissue expression of SLC19A1 - Summary - The Human Protein Atlas

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SLC19A1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SLC19A1
Gene description	Solute carrier family 19 (folate transporter), member 1
Protein class	Cancer-related genes Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues, most abundant in placenta.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA024802
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SLC19A1 (HGNC Symbol)
Synonyms	FOLT
Description	Solute carrier family 19 (folate transporter), member 1 (HGNC Symbol)
Entrez gene summary	The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
Chromosome	21
Cytoband	q22.3
Chromosome location (bp)	45493572 - 45544411
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173638 (version 83.38)
Entrez gene	6573
UniProt	P41440 (UniProt - Evidence at protein level)
neXtProt	NX_P41440
Antibodypedia	SLC19A1 antibodies

PROTEIN BROWSER

SLC19A1-001	SLC19A1-002	SLC19A1-003	SLC19A1-005	SLC19A1-007	SLC19A1-012	SLC19A1-014	SLC19A1-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC19A1-001 ENSP00000308895 ENST00000311124	P41440 [Direct mapping] Folate transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005542 [folic acid binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006810 [transport] GO:0007565 [female pregnancy] GO:0008517 [folic acid transporter activity] GO:0008518 [reduced folate carrier activity] GO:0015350 [methotrexate transporter activity] GO:0015884 [folic acid transport] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0031526 [brush border membrane] GO:0044281 [small molecule metabolic process] GO:0046655 [folic acid metabolic process] GO:0051958 [methotrexate transport] GO:0055085 [transmembrane transport] Show all	591 aa 64.9 kDa	No	>9
SLC19A1-002 ENSP00000369347 ENST00000380010	P41440 [Direct mapping] Folate transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005542 [folic acid binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006810 [transport] GO:0008517 [folic acid transporter activity] GO:0008518 [reduced folate carrier activity] GO:0015350 [methotrexate transporter activity] GO:0015884 [folic acid transport] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0044281 [small molecule metabolic process] GO:0046655 [folic acid metabolic process] GO:0051958 [methotrexate transport] GO:0055085 [transmembrane transport] Show all	489 aa 54.3 kDa	No	>9
SLC19A1-003 ENSP00000393988 ENST00000417954	H0Y4T2 [Direct mapping] Folate transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0008517 [folic acid transporter activity] GO:0015350 [methotrexate transporter activity] GO:0015884 [folic acid transport] GO:0016020 [membrane] GO:0051958 [methotrexate transport] Show all	269 aa 29.2 kDa	No	5
SLC19A1-005 ENSP00000411345 ENST00000443742	C9J8K6 [Direct mapping] Folate transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0008517 [folic acid transporter activity] GO:0015350 [methotrexate transporter activity] GO:0015884 [folic acid transport] GO:0016020 [membrane] GO:0051958 [methotrexate transport] Show all	154 aa 17.5 kDa	No	4
SLC19A1-007 ENSP00000401850 ENST00000427839	C9JKP4 [Direct mapping] Folate transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0008517 [folic acid transporter activity] GO:0015350 [methotrexate transporter activity] GO:0015884 [folic acid transport] GO:0016020 [membrane] GO:0051958 [methotrexate transport] Show all	182 aa 20.5 kDa	No	6
SLC19A1-012 ENSP00000435780 ENST00000528477	E9PIL5 [Direct mapping] Folate transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0008517 [folic acid transporter activity] GO:0015350 [methotrexate transporter activity] GO:0015884 [folic acid transport] GO:0016020 [membrane] GO:0051958 [methotrexate transport] Show all	61 aa 7 kDa	No	1
SLC19A1-014 ENSP00000457278 ENST00000567670	H3BTQ3 [Direct mapping] Folate transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0008517 [folic acid transporter activity] GO:0015350 [methotrexate transporter activity] GO:0015884 [folic acid transport] GO:0016020 [membrane] GO:0051958 [methotrexate transport] Show all	545 aa 60.1 kDa	No	>9
SLC19A1-015 ENSP00000441772 ENST00000485649	P41440 [Direct mapping] Folate transporter 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005542 [folic acid binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006810 [transport] GO:0008517 [folic acid transporter activity] GO:0008518 [reduced folate carrier activity] GO:0015350 [methotrexate transporter activity] GO:0015884 [folic acid transport] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0044281 [small molecule metabolic process] GO:0046655 [folic acid metabolic process] GO:0051958 [methotrexate transport] GO:0055085 [transmembrane transport] Show all	551 aa 60 kDa	No	>9

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.