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CNP

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GENERAL INFORMATION

Gene name

 CNP

Gene description

 2',3'-cyclic nucleotide 3' phosphodiesterase

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus. In addition localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (validated)

Additional location

 In addition localized to the Cytosol (validated)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA023266 , HPA023280
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus. In addition localized to the cytosol.

Main location

 Nucleus (validated)

Additional location

 Cytosol (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA023266 A-431 Nucleoplasm
Cytosol
HPA023266 U-2 OS Nucleoplasm
Cytosol
HPA023266 U-251 MG Nucleoplasm
Cytosol
HPA023280 A-431 Nucleoplasm
Cytosol
HPA023280 U-2 OS Nucleus
Cytosol
HPA023280 U-251 MG Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 CNP

Synonyms

Description

 2',3'-cyclic nucleotide 3' phosphodiesterase (HGNC Symbol)

Entrez gene summary

Chromosome

 17

Cytoband

 q21.2

Chromosome location (bp)

 41966741 - 41977731

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173786 (version 83.38)

Entrez gene

 1267

UniProt

 P09543 (UniProt - Evidence at protein level)

neXtProt

 NX_P09543

Antibodypedia

 CNP antibodies

PROTEIN BROWSER
CNP-001
CNP-002
CNP-003
CNP-004
CNP-007
CNP-010
CNP-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CNP-001
ENSP00000377470
ENST00000393892
P09543 [Direct mapping]
2',3'-cyclic-nucleotide 3'-phosphodiesterase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0003723 [RNA binding]
GO:0004113 [2',3'-cyclic-nucleotide 3'-phosphodiesterase activity]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0005743 [mitochondrial inner membrane]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0007268 [synaptic transmission]
GO:0007409 [axonogenesis]
GO:0007568 [aging]
GO:0008344 [adult locomotory behavior]
GO:0009214 [cyclic nucleotide catabolic process]
GO:0009636 [response to toxic substance]
GO:0016020 [membrane]
GO:0021762 [substantia nigra development]
GO:0030551 [cyclic nucleotide binding]
GO:0030900 [forebrain development]
GO:0031143 [pseudopodium]
GO:0032496 [response to lipopolysaccharide]
GO:0035748 [myelin sheath abaxonal region]
GO:0035749 [myelin sheath adaxonal region]
GO:0042470 [melanosome]
GO:0042995 [cell projection]
GO:0043209 [myelin sheath]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048709 [oligodendrocyte differentiation]
GO:0070062 [extracellular exosome]
Show all
 421 aa
47.6 kDa 		No 0
CNP-002
ENSP00000377466
ENST00000393888
P09543 [Direct mapping]
2',3'-cyclic-nucleotide 3'-phosphodiesterase
A0A024R1T5 [Target identity:100%; Query identity:100%]
2',3'-cyclic nucleotide 3' phosphodiesterase, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0004113 [2',3'-cyclic-nucleotide 3'-phosphodiesterase activity]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0007268 [synaptic transmission]
GO:0009214 [cyclic nucleotide catabolic process]
GO:0016020 [membrane]
GO:0021762 [substantia nigra development]
GO:0042470 [melanosome]
GO:0070062 [extracellular exosome]
Show all
 401 aa
45.1 kDa 		No 0
CNP-003
ENSP00000467641
ENST00000472031
K7EQ27 [Direct mapping]
2',3'-cyclic-nucleotide 3'-phosphodiesterase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 49 aa
5.4 kDa 		No 0
CNP-004
ENSP00000413104
ENST00000441615
C9K0L8 [Direct mapping]
2',3'-cyclic-nucleotide 3'-phosphodiesterase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004113 [2',3'-cyclic-nucleotide 3'-phosphodiesterase activity]
GO:0009214 [cyclic nucleotide catabolic process]
GO:0016020 [membrane]
Show all
 144 aa
16.5 kDa 		No 0
CNP-007
ENSP00000466807
ENST00000589772
K7EN66 [Direct mapping]
2',3'-cyclic-nucleotide 3'-phosphodiesterase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004113 [2',3'-cyclic-nucleotide 3'-phosphodiesterase activity]
GO:0009214 [cyclic nucleotide catabolic process]
GO:0016020 [membrane]
Show all
 120 aa
13.6 kDa 		No 0
CNP-010
ENSP00000468198
ENST00000587679
K7ERC4 [Direct mapping]
2',3'-cyclic-nucleotide 3'-phosphodiesterase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004113 [2',3'-cyclic-nucleotide 3'-phosphodiesterase activity]
GO:0009214 [cyclic nucleotide catabolic process]
GO:0016020 [membrane]
Show all
 165 aa
19.1 kDa 		No 0
CNP-011
ENSP00000468471
ENST00000585452
K7ERZ0 [Direct mapping]
2',3'-cyclic-nucleotide 3'-phosphodiesterase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004113 [2',3'-cyclic-nucleotide 3'-phosphodiesterase activity]
GO:0009214 [cyclic nucleotide catabolic process]
GO:0016020 [membrane]
Show all
 154 aa
17.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.