Tissue expression of KCNH6 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	KCNH6
Gene description	Potassium channel, voltage gated eag related subfamily H, member 6
Protein class	Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (kidney, small intestine, prostate)
GTEx:	Group enriched (pituitary gland, kidney, small intestine, prostate, testis, hypothalamus)
FANTOM5:	Tissue enhanced (kidney, pituitary gland, retina)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (kidney, small intestine, prostate)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (pituitary gland, kidney, small intestine, prostate, testis, hypothalamus)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (kidney, pituitary gland, retina)

GENE INFORMATION
Gene name	KCNH6 (HGNC Symbol)
Synonyms	erg2, HERG2, Kv11.2
Description	Potassium channel, voltage gated eag related subfamily H, member 6 (HGNC Symbol)
Entrez gene summary	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
Chromosome	17
Cytoband	q23.3
Chromosome location (bp)	63523334 - 63548977
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173826 (version 83.38)
Entrez gene	81033
UniProt	Q9H252 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H252
Antibodypedia	KCNH6 antibodies

PROTEIN BROWSER

KCNH6-001	KCNH6-002	KCNH6-003	KCNH6-005	KCNH6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNH6-001 ENSP00000318212 ENST00000314672	J9JID4 [Direct mapping] Potassium voltage-gated channel subfamily H member 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] GO:0086091 [regulation of heart rate by cardiac conduction] Show all	958 aa 106.4 kDa	No	6
KCNH6-002 ENSP00000463830 ENST00000581784	Q9H252 [Direct mapping] Potassium voltage-gated channel subfamily H member 6 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0007268 [synaptic transmission] GO:0016020 [membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] GO:0086091 [regulation of heart rate by cardiac conduction] Show all	905 aa 100.4 kDa	No	5
KCNH6-003 ENSP00000464672 ENST00000580652	Q9H252 [Direct mapping] Potassium voltage-gated channel subfamily H member 6 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0007268 [synaptic transmission] GO:0016020 [membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] GO:0086091 [regulation of heart rate by cardiac conduction] Show all	502 aa 56.3 kDa	No	4
KCNH6-005 ENSP00000463533 ENST00000583023	Q9H252 [Direct mapping] Potassium voltage-gated channel subfamily H member 6 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0007268 [synaptic transmission] GO:0016020 [membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] GO:0086091 [regulation of heart rate by cardiac conduction] Show all	994 aa 109.9 kDa	No	5
KCNH6-201 ENSP00000396900 ENST00000456941	Q9H252 [Direct mapping] Potassium voltage-gated channel subfamily H member 6 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0007268 [synaptic transmission] GO:0016020 [membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] GO:0086091 [regulation of heart rate by cardiac conduction] Show all	905 aa 100.4 kDa	No	5