Expression of MARCH10 in cancer - Summary

CANCER ATLAS

Gene description

Membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Glioma

STAINING SUMMARY

HPA023322

GENE INFORMATION
Gene name	MARCH10 (HGNC Symbol)
Synonyms	FLJ35757, MARCH-X, RNF190
Description	Membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary	MARCH10 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]
Chromosome	17
Cytoband	q23.2
Chromosome location (bp)	62701314 - 62808344
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173838 (version 83.38)
Entrez gene	162333
UniProt	Q8NA82 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NA82
Antibodypedia	MARCH10 antibodies

PROTEIN BROWSER

MARCH10-001	MARCH10-002	MARCH10-003	MARCH10-004	MARCH10-005	MARCH10-006	MARCH10-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MARCH10-001 ENSP00000311496 ENST00000311269	Q8NA82 [Direct mapping] Probable E3 ubiquitin-protein ligase MARCH10 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] Show all	808 aa 90.5 kDa	No	0
MARCH10-002 ENSP00000463080 ENST00000583600	J3KTN9 [Direct mapping] Probable E3 ubiquitin-protein ligase MARCH10; Ring finger protein 190, isoform CRA_b Show all	Predicted intracellular proteins Show all	GO:0008270 [zinc ion binding] Show all	846 aa 94.6 kDa	No	0
MARCH10-003 ENSP00000443746 ENST00000544856	G3V1Q5 [Direct mapping] Probable E3 ubiquitin-protein ligase MARCH10; Ring finger protein 190, isoform CRA_c Show all	Predicted intracellular proteins Show all	GO:0008270 [zinc ion binding] Show all	799 aa 89.8 kDa	No	0
MARCH10-004 ENSP00000416177 ENST00000456609	Q8NA82 [Direct mapping] Probable E3 ubiquitin-protein ligase MARCH10 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] Show all	808 aa 90.5 kDa	No	0
MARCH10-005 ENSP00000464220 ENST00000580520	J3QRH7 [Direct mapping] Probable E3 ubiquitin-protein ligase MARCH10 Show all	Predicted intracellular proteins Show all	GO:0008270 [zinc ion binding] Show all	693 aa 76.9 kDa	No	0
MARCH10-006 ENSP00000463029 ENST00000583803	J3KTK3 [Direct mapping] Probable E3 ubiquitin-protein ligase MARCH10 Show all	Predicted intracellular proteins Show all		61 aa 7.7 kDa	No	0
MARCH10-008 ENSP00000463572 ENST00000582568	J3QLJ2 [Direct mapping] Probable E3 ubiquitin-protein ligase MARCH10 Show all	Predicted intracellular proteins Show all		164 aa 17.8 kDa	No	0