Expression of GNG5 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Guanine nucleotide binding protein (G protein), gamma 5

Protein class

Predicted intracellular proteins, RAS pathway related proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Testis cancer

STAINING SUMMARY

HPA043651	CAB032623

GENE INFORMATION
Gene name	GNG5
Synonyms
Description	Guanine nucleotide binding protein (G protein), gamma 5 (HGNC Symbol)
Entrez gene summary	G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010]
Chromosome	1
Cytoband	p22.3
Chromosome location (bp)	84498325 - 84506565
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174021 (version 83.38)
Entrez gene	2787
UniProt	P63218 (UniProt - Evidence at protein level)
neXtProt	NX_P63218
Antibodypedia	GNG5 antibodies

PROTEIN BROWSER

GNG5-001	GNG5-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GNG5-001 ENSP00000359675 ENST00000370641	P63218 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005834 [heterotrimeric G-protein complex] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0016020 [membrane] GO:0030165 [PDZ domain binding] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] GO:0071377 [cellular response to glucagon stimulus] Show all	68 aa 7.3 kDa	No	0
GNG5-002 ENSP00000359679 ENST00000370645	P63218 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005834 [heterotrimeric G-protein complex] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0016020 [membrane] GO:0030165 [PDZ domain binding] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] GO:0071377 [cellular response to glucagon stimulus] Show all	68 aa 7.3 kDa	No	0