Expression of LEMD3 in cancer - Summary

CANCER ATLAS

Gene description

LEM domain containing 3

Protein class

Disease related genes, Plasma proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA025078

GENE INFORMATION
Gene name	LEMD3 (HGNC Symbol)
Synonyms	MAN1
Description	LEM domain containing 3 (HGNC Symbol)
Entrez gene summary	This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.[provided by RefSeq, Nov 2009]
Chromosome	12
Cytoband	q14.3
Chromosome location (bp)	65169571 - 65248327
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174106 (version 83.38)
Entrez gene	23592
UniProt	Q9Y2U8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2U8
Antibodypedia	LEMD3 antibodies

PROTEIN BROWSER

LEMD3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LEMD3-001 ENSP00000308369 ENST00000308330	Q9Y2U8 [Direct mapping] Inner nuclear membrane protein Man1 A0A024RBB9 [Target identity:100%; Query identity:100%] LEM domain containing 3, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0001525 [angiogenesis] GO:0002044 [blood vessel endothelial cell migration involved in intussusceptive angiogenesis] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005637 [nuclear inner membrane] GO:0005639 [integral component of nuclear inner membrane] GO:0006997 [nucleus organization] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030514 [negative regulation of BMP signaling pathway] GO:0032926 [negative regulation of activin receptor signaling pathway] GO:0035914 [skeletal muscle cell differentiation] GO:0051726 [regulation of cell cycle] GO:1903053 [regulation of extracellular matrix organization] Show all	911 aa 100 kDa	No	2