Tissue expression of TLR10 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TLR10
Gene description	Toll-like receptor 10
Protein class	CD markers Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (lymph node, tonsil, spleen, appendix)
GTEx:	Group enriched (spleen, small intestine)
FANTOM5:	Group enriched (appendix, spleen, tonsil, lymph node)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (lymph node, tonsil, spleen, appendix)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (spleen, small intestine)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (appendix, spleen, tonsil, lymph node)

GENE INFORMATION
Gene name	TLR10 (HGNC Symbol)
Synonyms	CD290
Description	Toll-like receptor 10 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
Chromosome	4
Cytoband	p14
Chromosome location (bp)	38772239 - 38782990
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174123 (version 83.38)
Entrez gene	81793
UniProt	Q9BXR5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BXR5
Antibodypedia	TLR10 antibodies

PROTEIN BROWSER

TLR10-001	TLR10-002	TLR10-003	TLR10-004	TLR10-201	TLR10-202	TLR10-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TLR10-001 ENSP00000308925 ENST00000308973	Q9BXR5 [Direct mapping] Toll-like receptor 10 A0A024R9W4 [Target identity:100%; Query identity:100%] Toll-like receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0045087 [innate immune response] GO:0050707 [regulation of cytokine secretion] GO:0050729 [positive regulation of inflammatory response] Show all	811 aa 94.6 kDa	Yes	1
TLR10-002 ENSP00000424923 ENST00000508334	Q9BXR5 [Direct mapping] Toll-like receptor 10 A0A024R9W4 [Target identity:100%; Query identity:100%] Toll-like receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Show all	GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0045087 [innate immune response] GO:0050707 [regulation of cytokine secretion] GO:0050729 [positive regulation of inflammatory response] Show all	811 aa 94.6 kDa	Yes	1
TLR10-003 ENSP00000421483 ENST00000506111	Q9BXR5 [Direct mapping] Toll-like receptor 10 A0A024R9W4 [Target identity:100%; Query identity:100%] Toll-like receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Show all	GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0045087 [innate immune response] GO:0050707 [regulation of cytokine secretion] GO:0050729 [positive regulation of inflammatory response] Show all	811 aa 94.6 kDa	Yes	1
TLR10-004 ENSP00000427606 ENST00000502321	D6RHW6 [Direct mapping] Toll-like receptor 10 Show all	Predicted intracellular proteins Show all	GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0045087 [innate immune response] GO:0050707 [regulation of cytokine secretion] GO:0050729 [positive regulation of inflammatory response] Show all	94 aa 10.9 kDa	No	0
TLR10-201 ENSP00000354459 ENST00000361424	Q9BXR5 [Direct mapping] Toll-like receptor 10 A0A024R9W4 [Target identity:100%; Query identity:100%] Toll-like receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0045087 [innate immune response] GO:0050707 [regulation of cytokine secretion] GO:0050729 [positive regulation of inflammatory response] Show all	811 aa 94.6 kDa	Yes	1
TLR10-202 ENSP00000478206 ENST00000613579	Q9BXR5 [Direct mapping] Toll-like receptor 10 A0A024R9W4 [Target identity:100%; Query identity:100%] Toll-like receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0045087 [innate immune response] GO:0050707 [regulation of cytokine secretion] GO:0050729 [positive regulation of inflammatory response] Show all	811 aa 94.6 kDa	Yes	1
TLR10-203 ENSP00000478985 ENST00000622002	Q9BXR5 [Direct mapping] Toll-like receptor 10 A0A024R9W4 [Target identity:100%; Query identity:100%] Toll-like receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0045087 [innate immune response] GO:0050707 [regulation of cytokine secretion] GO:0050729 [positive regulation of inflammatory response] Show all	811 aa 94.6 kDa	Yes	1