Fields »
ABOUT
HELP
BLOG
TLR1

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 TLR1

Gene description

 Toll-like receptor 1

Protein class

 CD markers
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (U-698, HUVEC TERT2, RPMI-8226)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-698, HUVEC TERT2, RPMI-8226)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 TLR1 (HGNC Symbol)

Synonyms

 CD281, KIAA0012, rsc786

Description

 Toll-like receptor 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 p14

Chromosome location (bp)

 38790677 - 38856817

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000174125 (version 83.38)

Entrez gene

 7096

UniProt

 Q15399 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15399

Antibodypedia

 TLR1 antibodies

PROTEIN BROWSER
TLR1-001
TLR1-004
TLR1-005
TLR1-006
TLR1-007
TLR1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TLR1-001
ENSP00000421259
ENST00000502213
Q15399 [Direct mapping]
Toll-like receptor 1
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030670 [phagocytic vesicle membrane]
GO:0034130 [toll-like receptor 1 signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035354 [Toll-like receptor 1-Toll-like receptor 2 protein complex]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042116 [macrophage activation]
GO:0042495 [detection of triacyl bacterial lipopeptide]
GO:0042535 [positive regulation of tumor necrosis factor biosynthetic process]
GO:0045087 [innate immune response]
GO:0045410 [positive regulation of interleukin-6 biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0050707 [regulation of cytokine secretion]
GO:0071727 [cellular response to triacyl bacterial lipopeptide]
Show all
 786 aa
90.3 kDa 		Yes 1
TLR1-004
ENSP00000423725
ENST00000506146
D6RCE8 [Direct mapping]
Toll-like receptor 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Show all
 48 aa
5.6 kDa 		Yes 0
TLR1-005
ENSP00000421856
ENST00000505940
D6RAP2 [Direct mapping]
Toll-like receptor 1
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Show all
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0006954 [inflammatory response]
GO:0016021 [integral component of membrane]
GO:0034130 [toll-like receptor 1 signaling pathway]
GO:0042116 [macrophage activation]
GO:0042495 [detection of triacyl bacterial lipopeptide]
GO:0050707 [regulation of cytokine secretion]
Show all
 161 aa
18.6 kDa 		Yes 0
TLR1-006
ENSP00000423017
ENST00000515861
D6RA99 [Direct mapping]
Toll-like receptor 1
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Show all
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0004888 [transmembrane signaling receptor activity]
GO:0006954 [inflammatory response]
GO:0016021 [integral component of membrane]
GO:0034130 [toll-like receptor 1 signaling pathway]
GO:0042116 [macrophage activation]
GO:0042495 [detection of triacyl bacterial lipopeptide]
GO:0050707 [regulation of cytokine secretion]
Show all
 90 aa
10.5 kDa 		Yes 0
TLR1-007
ENSP00000424894
ENST00000508364
D6RF68 [Direct mapping]
Toll-like receptor 1
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
 23 aa
2.8 kDa 		No 0
TLR1-201
ENSP00000354932
ENST00000308979
Q15399 [Direct mapping]
Toll-like receptor 1
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006952 [defense response]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030670 [phagocytic vesicle membrane]
GO:0034130 [toll-like receptor 1 signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035354 [Toll-like receptor 1-Toll-like receptor 2 protein complex]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042116 [macrophage activation]
GO:0042495 [detection of triacyl bacterial lipopeptide]
GO:0042535 [positive regulation of tumor necrosis factor biosynthetic process]
GO:0045087 [innate immune response]
GO:0045410 [positive regulation of interleukin-6 biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0050707 [regulation of cytokine secretion]
GO:0071727 [cellular response to triacyl bacterial lipopeptide]
Show all
 786 aa
90.3 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.