Tissue expression of SELP - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SELP
Gene description	Selectin P (granule membrane protein 140kDa, antigen CD62)
Protein class	Cancer-related genes Candidate cardiovascular disease genes CD markers Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

Protein expression

Highly selective expression in megakaryocytes, platelets and endothelial cells.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Protein expression in megakaryocytes cannot be correlated with bone marrow RNA-seq data due to cell type not available.
Reliability score	Supported based on 3 antibodies. HPA002655 , HPA005990 , CAB002145
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	SELP (HGNC Symbol)
Synonyms	CD62, CD62P, GMP140, GRMP, PADGEM, PSEL
Description	Selectin P (granule membrane protein 140kDa, antigen CD62) (HGNC Symbol)
Entrez gene summary	This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q24.2
Chromosome location (bp)	169588849 - 169630193
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174175 (version 83.38)
Entrez gene	6403
UniProt	P16109 (UniProt - Evidence at protein level)
neXtProt	NX_P16109
Antibodypedia	SELP antibodies

PROTEIN BROWSER

SELP-001	SELP-002	SELP-004	SELP-005	SELP-006	SELP-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SELP-001 ENSP00000263686 ENST00000263686	P16109 [Direct mapping] P-selectin A0A024R8Y9 [Target identity:100%; Query identity:100%] Selectin P (Granule membrane protein 140kDa, antigen CD62), isoform CRA_b Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Candidate cardiovascular disease genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001530 [lipopolysaccharide binding] GO:0001948 [glycoprotein binding] GO:0002576 [platelet degranulation] GO:0002687 [positive regulation of leukocyte migration] GO:0002691 [regulation of cellular extravasation] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007159 [leukocyte cell-cell adhesion] GO:0007596 [blood coagulation] GO:0008201 [heparin binding] GO:0009897 [external side of plasma membrane] GO:0010572 [positive regulation of platelet activation] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014070 [response to organic cyclic compound] GO:0016020 [membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0030168 [platelet activation] GO:0031088 [platelet dense granule membrane] GO:0031092 [platelet alpha granule membrane] GO:0032496 [response to lipopolysaccharide] GO:0033623 [regulation of integrin activation] GO:0033691 [sialic acid binding] GO:0035584 [calcium-mediated signaling using intracellular calcium source] GO:0042806 [fucose binding] GO:0043208 [glycosphingolipid binding] GO:0045785 [positive regulation of cell adhesion] GO:0048306 [calcium-dependent protein binding] GO:0050829 [defense response to Gram-negative bacterium] GO:0050900 [leukocyte migration] GO:0050901 [leukocyte tethering or rolling] GO:0070492 [oligosaccharide binding] Show all	830 aa 90.8 kDa	No	1
SELP-002 ENSP00000391694 ENST00000426706	Q5R349 [Direct mapping] P-selectin Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0007155 [cell adhesion] GO:0016020 [membrane] Show all	789 aa 86.5 kDa	No	0
SELP-004 ENSP00000399368 ENST00000458599	Q5R342 [Direct mapping] P-selectin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] Show all	646 aa 70.9 kDa	No	1
SELP-005 ENSP00000356760 ENST00000367786	Q5R341 [Direct mapping] P-selectin; Selectin P (Granule membrane protein 140kDa, antigen CD62), isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	768 aa 84 kDa	No	1
SELP-006 ENSP00000356762 ENST00000367788	Q5R345 [Direct mapping] P-selectin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] Show all	768 aa 84.3 kDa	No	1
SELP-008 ENSP00000356769 ENST00000367795	F6VVT6 [Direct mapping] P-selectin Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0016020 [membrane] Show all	444 aa 49.6 kDa	No	0