Tissue expression of MGA - Summary - The Human Protein Atlas

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MGA

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MGA
Gene description	MGA, MAX dimerization protein
Protein class	Cancer-related genes Predicted intracellular proteins Predicted secreted proteins Transcription factors
Predicted localization	Intracellular,Secreted
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Nuclear expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA042278
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	MGA (HGNC Symbol)
Synonyms	FLJ12634, KIAA0518, MAD5, MXD5
Description	MGA, MAX dimerization protein (HGNC Symbol)
Entrez gene summary
Chromosome	15
Cytoband	q15.1
Chromosome location (bp)	41621224 - 41773081
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174197 (version 83.38)
Entrez gene	23269
UniProt	Q8IWI9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IWI9
Antibodypedia	MGA antibodies

PROTEIN BROWSER

MGA-001	MGA-002	MGA-003	MGA-004	MGA-005	MGA-008	MGA-201	MGA-202	MGA-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MGA-001 ENSP00000456141 ENST00000566586	Q8IWI9 [Direct mapping] MAX gene-associated protein Show all	Predicted intracellular proteins Transcription factors Basic domains Immunoglobulin fold Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046983 [protein dimerization activity] GO:0071339 [MLL1 complex] Show all	2856 aa 315.2 kDa	No	0
MGA-002 ENSP00000457151 ENST00000563576	H3BTF4 [Direct mapping] MAX gene-associated protein Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	1138 aa 126.7 kDa	No	0
MGA-003 ENSP00000457474 ENST00000564190	H3BU53 [Direct mapping] MAX gene-associated protein Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0046983 [protein dimerization activity] Show all	1174 aa 127.1 kDa	No	0
MGA-004 ENSP00000455155 ENST00000566718	H3BP52 [Direct mapping] MAX gene-associated protein Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	1086 aa 120.6 kDa	No	0
MGA-005 ENSP00000457035 ENST00000570161	Q8IWI9 [Direct mapping] MAX gene-associated protein Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Transcription factors Basic domains Immunoglobulin fold Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046983 [protein dimerization activity] GO:0071339 [MLL1 complex] Show all	3065 aa 336.2 kDa	No	0
MGA-008 ENSP00000457250 ENST00000561532	H3BTN2 [Direct mapping] MAX gene-associated protein Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	83 aa 9 kDa	No	0
MGA-201 ENSP00000219905 ENST00000219905	Q8IWI9 [Direct mapping] MAX gene-associated protein Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Transcription factors Basic domains Immunoglobulin fold Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046983 [protein dimerization activity] GO:0071339 [MLL1 complex] Show all	3065 aa 336.2 kDa	No	0
MGA-202 ENSP00000442467 ENST00000545763	Q8IWI9 [Direct mapping] MAX gene-associated protein Show all	Predicted intracellular proteins Transcription factors Basic domains Immunoglobulin fold Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046983 [protein dimerization activity] GO:0071339 [MLL1 complex] Show all	2856 aa 315.2 kDa	No	0
MGA-203 ENSP00000483990 ENST00000619521	A0A087X194 [Direct mapping] MAX gene-associated protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		61 aa 7.1 kDa	Yes	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.