Expression of RPL4 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Ribosomal protein L4

Protein class

Plasma proteins, Predicted intracellular proteins, Ribosomal proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA034600

GENE INFORMATION
Gene name	RPL4 (HGNC Symbol)
Synonyms	L4
Description	Ribosomal protein L4 (HGNC Symbol)
Entrez gene summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L4E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q22.31
Chromosome location (bp)	66498015 - 66524532
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174444 (version 83.38)
Entrez gene	6124
UniProt	P36578 (UniProt - Evidence at protein level)
neXtProt	NX_P36578
Antibodypedia	RPL4 antibodies

PROTEIN BROWSER

RPL4-001	RPL4-010	RPL4-012	RPL4-020

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RPL4-001 ENSP00000311430 ENST00000307961	P36578 [Direct mapping] 60S ribosomal protein L4 Show all	Ribosomal proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0002181 [cytoplasmic translation] GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005840 [ribosome] GO:0005925 [focal adhesion] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0006414 [translational elongation] GO:0006415 [translational termination] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016032 [viral process] GO:0019058 [viral life cycle] GO:0019083 [viral transcription] GO:0022625 [cytosolic large ribosomal subunit] GO:0030529 [ribonucleoprotein complex] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0070062 [extracellular exosome] Show all	427 aa 47.7 kDa	No	0
RPL4-010 ENSP00000457442 ENST00000569696	H3BU31 [Direct mapping] 60S ribosomal protein L4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005840 [ribosome] GO:0006412 [translation] Show all	171 aa 19 kDa	No	0
RPL4-012 ENSP00000457268 ENST00000569438	H3BTP7 [Direct mapping] 60S ribosomal protein L4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005840 [ribosome] GO:0006412 [translation] Show all	170 aa 18.8 kDa	No	0
RPL4-020 ENSP00000454281 ENST00000568588	H3BM89 [Direct mapping] 60S ribosomal protein L4; Ribosomal protein L4, isoform CRA_a Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation] Show all	333 aa 37.7 kDa	No	0