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Cancer tissues were generally weakly stained. Cytoplasmic staining of moderate intensity was observed in a few carcinoids and pancreatic cancers.
GENE INFORMATION
Gene name
GCSAM (HGNC Symbol)
Synonyms
GCET2, HGAL, MGC40441
Description
Germinal center-associated, signaling and motility (HGNC Symbol)
Entrez gene summary
This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]