Expression of CMKLR1 in cancer - Summary

CANCER ATLAS

Gene description

Chemerin chemokine-like receptor 1

Protein class

G-protein coupled receptors, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Thyroid cancer

STAINING SUMMARY

HPA047865

GENE INFORMATION
Gene name	CMKLR1 (HGNC Symbol)
Synonyms	RVER1
Description	Chemerin chemokine-like receptor 1 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q23.3
Chromosome location (bp)	108288044 - 108339341
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174600 (version 83.38)
Entrez gene	1240
UniProt	Q99788 (UniProt - Evidence at protein level)
neXtProt	NX_Q99788
Antibodypedia	CMKLR1 antibodies

PROTEIN BROWSER

CMKLR1-001	CMKLR1-002	CMKLR1-003	CMKLR1-004	CMKLR1-005	CMKLR1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CMKLR1-001 ENSP00000311733 ENST00000312143	Q99788 [Direct mapping] Chemokine-like receptor 1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0001501 [skeletal system development] GO:0004872 [receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006955 [immune response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0010759 [positive regulation of macrophage chemotaxis] GO:0016021 [integral component of membrane] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032695 [negative regulation of interleukin-12 production] GO:0045600 [positive regulation of fat cell differentiation] GO:0050848 [regulation of calcium-mediated signaling] GO:0070098 [chemokine-mediated signaling pathway] Show all	373 aa 42.3 kDa	No	7
CMKLR1-002 ENSP00000449716 ENST00000550402	Q99788 [Direct mapping] Chemokine-like receptor 1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0001501 [skeletal system development] GO:0004872 [receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006955 [immune response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0010759 [positive regulation of macrophage chemotaxis] GO:0016021 [integral component of membrane] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032695 [negative regulation of interleukin-12 production] GO:0045600 [positive regulation of fat cell differentiation] GO:0050848 [regulation of calcium-mediated signaling] GO:0070098 [chemokine-mediated signaling pathway] Show all	373 aa 42.3 kDa	No	7
CMKLR1-003 ENSP00000448925 ENST00000550573	F8VYN7 [Direct mapping] Chemokine-like receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	147 aa 16.9 kDa	No	3
CMKLR1-004 ENSP00000448362 ENST00000549466	F8VSC8 [Direct mapping] Chemokine-like receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	143 aa 16.4 kDa	No	3
CMKLR1-005 ENSP00000447579 ENST00000552995	Q99788 [Direct mapping] Chemokine-like receptor 1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0001501 [skeletal system development] GO:0004872 [receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006955 [immune response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0010759 [positive regulation of macrophage chemotaxis] GO:0016021 [integral component of membrane] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032695 [negative regulation of interleukin-12 production] GO:0045600 [positive regulation of fat cell differentiation] GO:0050848 [regulation of calcium-mediated signaling] GO:0070098 [chemokine-mediated signaling pathway] Show all	371 aa 42 kDa	No	7
CMKLR1-201 ENSP00000401293 ENST00000412676	Q99788 [Direct mapping] Chemokine-like receptor 1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0001501 [skeletal system development] GO:0004872 [receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006955 [immune response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0010759 [positive regulation of macrophage chemotaxis] GO:0016021 [integral component of membrane] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032695 [negative regulation of interleukin-12 production] GO:0045600 [positive regulation of fat cell differentiation] GO:0050848 [regulation of calcium-mediated signaling] GO:0070098 [chemokine-mediated signaling pathway] Show all	373 aa 42.3 kDa	No	7