Tissue expression of SLC29A2 - Summary - The Human Protein Atlas

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SLC29A2

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SLC29A2
Gene description	Solute carrier family 29 (equilibrative nucleoside transporter), member 2
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (skeletal muscle)
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Nuclear and cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA018168
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

Skeletal muscle

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (skeletal muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SLC29A2 (HGNC Symbol)
Synonyms	DER12, ENT2, HNP36
Description	Solute carrier family 29 (equilibrative nucleoside transporter), member 2 (HGNC Symbol)
Entrez gene summary	The uptake of nucleosides by transporters, such as SLC29A2, is essential for nucleotide synthesis by salvage pathways in cells that lack de novo biosynthetic pathways. Nucleoside transport also plays a key role in the regulation of many physiologic processes through its effect on adenosine concentration at the cell surface (Griffiths et al., 1997 [PubMed 9396714]).[supplied by OMIM, Nov 2008]
Chromosome	11
Cytoband	q13.2
Chromosome location (bp)	66362521 - 66372214
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174669 (version 83.38)
Entrez gene	3177
UniProt	Q14542 (UniProt - Evidence at protein level)
neXtProt	NX_Q14542
Antibodypedia	SLC29A2 antibodies

PROTEIN BROWSER

SLC29A2-001	SLC29A2-004	SLC29A2-005	SLC29A2-006	SLC29A2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC29A2-001 ENSP00000440329 ENST00000546034	Q14542 [Direct mapping] Equilibrative nucleoside transporter 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005337 [nucleoside transmembrane transporter activity] GO:0005730 [nucleolus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006810 [transport] GO:0008283 [cell proliferation] GO:0015858 [nucleoside transport] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0031965 [nuclear membrane] GO:0055085 [transmembrane transport] GO:1901642 [nucleoside transmembrane transport] Show all	456 aa 50.1 kDa	No	>9
SLC29A2-004 ENSP00000439456 ENST00000544554	Q14542 [Direct mapping] Equilibrative nucleoside transporter 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005337 [nucleoside transmembrane transporter activity] GO:0005730 [nucleolus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006810 [transport] GO:0008283 [cell proliferation] GO:0015858 [nucleoside transport] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0031965 [nuclear membrane] GO:0055085 [transmembrane transport] GO:1901642 [nucleoside transmembrane transport] Show all	456 aa 50.1 kDa	No	>9
SLC29A2-005 ENSP00000311250 ENST00000311161	G5E943 [Direct mapping] Equilibrative nucleoside transporter 2; Solute carrier family 29 (Nucleoside transporters), member 2, isoform CRA_d Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005337 [nucleoside transmembrane transporter activity] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0016021 [integral component of membrane] GO:1901642 [nucleoside transmembrane transport] Show all	361 aa 38.8 kDa	No	6
SLC29A2-006 ENSP00000350024 ENST00000357440	Q14542 [Direct mapping] Equilibrative nucleoside transporter 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005337 [nucleoside transmembrane transporter activity] GO:0005730 [nucleolus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006810 [transport] GO:0008283 [cell proliferation] GO:0015858 [nucleoside transport] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0031965 [nuclear membrane] GO:0055085 [transmembrane transport] GO:1901642 [nucleoside transmembrane transport] Show all	456 aa 50.1 kDa	No	>9
SLC29A2-201 ENSP00000481944 ENST00000619145	G5E943 [Direct mapping] Equilibrative nucleoside transporter 2; Solute carrier family 29 (Nucleoside transporters), member 2, isoform CRA_d Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005337 [nucleoside transmembrane transporter activity] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0016021 [integral component of membrane] GO:1901642 [nucleoside transmembrane transport] Show all	361 aa 38.8 kDa	No	6

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.