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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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LEP
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CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Leptin

Protein class

Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB010490

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cases of melanomas, breast, prostate and female genital cancers showed weak cytoplasmic immunoreactivity. Remaining cancer tissues were generally negative.

GENE INFORMATION

Gene name

LEP (HGNC Symbol)

Synonyms

OB, OBS

Description

Leptin (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

q32.1

Chromosome location (bp)

128241284 - 128257628

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000174697 (version 83.38)

Entrez gene

3952

UniProt

P41159 (UniProt - Evidence at protein level)

neXtProt

NX_P41159

Antibodypedia

LEP antibodies

PROTEIN BROWSER

LEP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LEP-001
ENSP00000312652
ENST00000308868
P41159 [Direct mapping]
Leptin
A4D0Y8 [Target identity:100%; Query identity:100%]
Leptin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001542 [ovulation from ovarian follicle]
GO:0001666 [response to hypoxia]
GO:0001819 [positive regulation of cytokine production]
GO:0001890 [placenta development]
GO:0001932 [regulation of protein phosphorylation]
GO:0002021 [response to dietary excess]
GO:0003300 [cardiac muscle hypertrophy]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005623 [cell]
GO:0005737 [cytoplasm]
GO:0006006 [glucose metabolic process]
GO:0006111 [regulation of gluconeogenesis]
GO:0006112 [energy reserve metabolic process]
GO:0006114 [glycerol biosynthetic process]
GO:0006629 [lipid metabolic process]
GO:0006635 [fatty acid beta-oxidation]
GO:0007165 [signal transduction]
GO:0007260 [tyrosine phosphorylation of STAT protein]
GO:0007565 [female pregnancy]
GO:0007584 [response to nutrient]
GO:0007623 [circadian rhythm]
GO:0008083 [growth factor activity]
GO:0008203 [cholesterol metabolic process]
GO:0008206 [bile acid metabolic process]
GO:0008217 [regulation of blood pressure]
GO:0008284 [positive regulation of cell proliferation]
GO:0008343 [adult feeding behavior]
GO:0009062 [fatty acid catabolic process]
GO:0009892 [negative regulation of metabolic process]
GO:0010888 [negative regulation of lipid storage]
GO:0014823 [response to activity]
GO:0019222 [regulation of metabolic process]
GO:0021954 [central nervous system neuron development]
GO:0030073 [insulin secretion]
GO:0030300 [regulation of intestinal cholesterol absorption]
GO:0031667 [response to nutrient levels]
GO:0032099 [negative regulation of appetite]
GO:0032355 [response to estradiol]
GO:0032868 [response to insulin]
GO:0033197 [response to vitamin E]
GO:0033210 [leptin-mediated signaling pathway]
GO:0033686 [positive regulation of luteinizing hormone secretion]
GO:0035360 [positive regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0035630 [bone mineralization involved in bone maturation]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042445 [hormone metabolic process]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042593 [glucose homeostasis]
GO:0042755 [eating behavior]
GO:0043066 [negative regulation of apoptotic process]
GO:0043270 [positive regulation of ion transport]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045471 [response to ethanol]
GO:0045598 [regulation of fat cell differentiation]
GO:0045639 [positive regulation of myeloid cell differentiation]
GO:0045906 [negative regulation of vasoconstriction]
GO:0046427 [positive regulation of JAK-STAT cascade]
GO:0046628 [positive regulation of insulin receptor signaling pathway]
GO:0046881 [positive regulation of follicle-stimulating hormone secretion]
GO:0048639 [positive regulation of developmental growth]
GO:0050796 [regulation of insulin secretion]
GO:0050810 [regulation of steroid biosynthetic process]
GO:0050901 [leukocyte tethering or rolling]
GO:0051428 [peptide hormone receptor binding]
GO:0060587 [regulation of lipoprotein lipid oxidation]
GO:0060612 [adipose tissue development]
GO:0061037 [negative regulation of cartilage development]
GO:0070093 [negative regulation of glucagon secretion]
GO:0071298 [cellular response to L-ascorbic acid]
GO:0071300 [cellular response to retinoic acid]
GO:1900180 [regulation of protein localization to nucleus]
GO:1904651 [positive regulation of fat cell apoptotic process]
GO:2000366 [positive regulation of STAT protein import into nucleus]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2000486 [negative regulation of glutamine transport]
GO:2000491 [positive regulation of hepatic stellate cell activation]
Show all
167 aa
18.6 kDa
Yes 0

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