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SRP72

CANCER ATLAS

Gene description

 Signal recognition particle 72kDa

Protein class

 Disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA034621

GENE INFORMATION

Gene name

 SRP72

Synonyms

Description

 Signal recognition particle 72kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of secretory proteins to the endoplasmic reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein subunits: SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72, that are bound to the 7S RNA as monomers or heterodimers. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein. Mutations in this gene are associated with familial bone marrow failure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

Chromosome

 4

Cytoband

 q12

Chromosome location (bp)

 56466915 - 56503680

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000174780 (version 83.38)

Entrez gene

 6731

UniProt

 O76094 (UniProt - Evidence at protein level)

neXtProt

 NX_O76094

Antibodypedia

 SRP72 antibodies

PROTEIN BROWSER
SRP72-001
SRP72-002
SRP72-005
SRP72-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SRP72-001
ENSP00000342181
ENST00000342756
O76094 [Direct mapping]
Signal recognition particle subunit SRP72
V9HWK0 [Target identity:100%; Query identity:100%]
Signal recognition particle subunit SRP72
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005047 [signal recognition particle binding]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005786 [signal recognition particle, endoplasmic reticulum targeting]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006412 [translation]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0008312 [7S RNA binding]
GO:0010467 [gene expression]
GO:0042493 [response to drug]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0048500 [signal recognition particle]
Show all
 671 aa
74.6 kDa 		No 0
SRP72-002
ENSP00000425190
ENST00000505314
D6RDY6 [Direct mapping]
Signal recognition particle subunit SRP72
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
Show all
 357 aa
39.6 kDa 		No 0
SRP72-005
ENSP00000424576
ENST00000510663
O76094 [Direct mapping]
Signal recognition particle subunit SRP72
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005047 [signal recognition particle binding]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005786 [signal recognition particle, endoplasmic reticulum targeting]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006412 [translation]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0008312 [7S RNA binding]
GO:0010467 [gene expression]
GO:0042493 [response to drug]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0048500 [signal recognition particle]
Show all
 610 aa
67.9 kDa 		No 0
SRP72-008
ENSP00000473576
ENST00000504757
R4GNC1 [Direct mapping]
Signal recognition particle subunit SRP72
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
Show all
 220 aa
24.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.