Expression of ADGRE1 in cancer - Summary

CANCER ATLAS

Gene description

Adhesion G protein-coupled receptor E1

Protein class

G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA052809

GENE INFORMATION
Gene name	ADGRE1 (HGNC Symbol)
Synonyms	EMR1, TM7LN3
Description	Adhesion G protein-coupled receptor E1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Chromosome	19
Cytoband
Chromosome location (bp)	6887566 - 6940459
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000174837 (version 83.38)
Entrez gene	2015
UniProt	Q14246 (UniProt - Evidence at transcript level)
neXtProt	NX_Q14246
Antibodypedia	ADGRE1 antibodies

PROTEIN BROWSER

ADGRE1-001	ADGRE1-002	ADGRE1-003	ADGRE1-004	ADGRE1-005	ADGRE1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADGRE1-001 ENSP00000250572 ENST00000250572	Q14246 [Direct mapping] Adhesion G protein-coupled receptor E1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0002250 [adaptive immune response] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	821 aa 90.4 kDa	Yes	5
ADGRE1-002 ENSP00000311545 ENST00000312053	Q14246 [Direct mapping] Adhesion G protein-coupled receptor E1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0002250 [adaptive immune response] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0009897 [external side of plasma membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0071944 [cell periphery] Show all	886 aa 97.7 kDa	Yes	7
ADGRE1-003 ENSP00000370814 ENST00000381407	Q14246 [Direct mapping] Adhesion G protein-coupled receptor E1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0002250 [adaptive immune response] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	745 aa 82.8 kDa	Yes	7
ADGRE1-004 ENSP00000370811 ENST00000381404	Q14246 [Direct mapping] Adhesion G protein-coupled receptor E1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0002250 [adaptive immune response] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	867 aa 95.9 kDa	Yes	7
ADGRE1-005 ENSP00000405974 ENST00000450315	Q14246 [Direct mapping] Adhesion G protein-coupled receptor E1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0002250 [adaptive immune response] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	709 aa 78.9 kDa	Yes	7
ADGRE1-008 ENSP00000472553 ENST00000595026	M0R2G7 [Direct mapping] Adhesion G protein-coupled receptor E1 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	319 aa 34.5 kDa	No	0