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Melanomas showed moderate to strong cytoplasmic positivity. Moderate cytoplasmic immunoreactivity often combined with nucleolar staining was observed in several cases of colorectal, prostate, testicular, pancreatic and liver cancers. Membranous positivity was observed in a few cases.Other cancer tissues were weakly stained or negative.
Most cancer tissues showed moderate to strong cytoplasmic with additional membranous positivity in some cases. Lymphomas and several cases of prostate cancers were negative.
GENE INFORMATION
Gene name
PTDSS2 (HGNC Symbol)
Synonyms
PSS2
Description
Phosphatidylserine synthase 2 (HGNC Symbol)
Entrez gene summary
Phosphatidylserine (PS) accounts for 5 to 10% of cell membrane phospholipids. In addition to its role as a structural component, PS is involved in cell signaling, blood coagulation, and apoptosis. PS is synthesized by a calcium-dependent base-exchange reaction catalyzed by PS synthases (EC 2.7.8.8), like PTDSS2, that exchange L-serine for the polar head group of phosphatidylcholine (PC) or phosphatidylethanolamine (PE) (Sturbois-Balcerzak et al., 2001 [PubMed 11084049]).[supplied by OMIM, May 2009]
