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DHX36

CANCER ATLAS

Gene description

 DEAH (Asp-Glu-Ala-His) box polypeptide 36

Protein class

 Enzymes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035399

GENE INFORMATION

Gene name

 DHX36 (HGNC Symbol)

Synonyms

 DDX36, KIAA1488, MLEL1

Description

 DEAH (Asp-Glu-Ala-His) box polypeptide 36 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q25.2

Chromosome location (bp)

 154272546 - 154324497

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000174953 (version 83.38)

Entrez gene

 170506

UniProt

 Q9H2U1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H2U1

Antibodypedia

 DHX36 antibodies

PROTEIN BROWSER
DHX36-001
DHX36-002
DHX36-003
DHX36-004
DHX36-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DHX36-001
ENSP00000417078
ENST00000496811
Q9H2U1 [Direct mapping]
ATP-dependent RNA helicase DHX36
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0001047 [core promoter binding]
GO:0001503 [ossification]
GO:0002151 [G-quadruplex RNA binding]
GO:0003676 [nucleic acid binding]
GO:0003725 [double-stranded RNA binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006396 [RNA processing]
GO:0008026 [ATP-dependent helicase activity]
GO:0008094 [DNA-dependent ATPase activity]
GO:0009615 [response to virus]
GO:0010501 [RNA secondary structure unwinding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032481 [positive regulation of type I interferon production]
GO:0042826 [histone deacetylase binding]
GO:0043330 [response to exogenous dsRNA]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051880 [G-quadruplex DNA binding]
GO:0070062 [extracellular exosome]
Show all
 1008 aa
114.8 kDa 		No 0
DHX36-002
ENSP00000309296
ENST00000308361
Q9H2U1 [Direct mapping]
ATP-dependent RNA helicase DHX36
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0001047 [core promoter binding]
GO:0001503 [ossification]
GO:0002151 [G-quadruplex RNA binding]
GO:0003676 [nucleic acid binding]
GO:0003725 [double-stranded RNA binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006396 [RNA processing]
GO:0008026 [ATP-dependent helicase activity]
GO:0008094 [DNA-dependent ATPase activity]
GO:0010501 [RNA secondary structure unwinding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032481 [positive regulation of type I interferon production]
GO:0042826 [histone deacetylase binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051880 [G-quadruplex DNA binding]
GO:0070062 [extracellular exosome]
Show all
 979 aa
111.5 kDa 		No 0
DHX36-003
ENSP00000330113
ENST00000329463
Q9H2U1 [Direct mapping]
ATP-dependent RNA helicase DHX36
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000781 [chromosome, telomeric region]
GO:0001047 [core promoter binding]
GO:0001503 [ossification]
GO:0002151 [G-quadruplex RNA binding]
GO:0003676 [nucleic acid binding]
GO:0003725 [double-stranded RNA binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006396 [RNA processing]
GO:0008026 [ATP-dependent helicase activity]
GO:0008094 [DNA-dependent ATPase activity]
GO:0010501 [RNA secondary structure unwinding]
GO:0032206 [positive regulation of telomere maintenance]
GO:0032481 [positive regulation of type I interferon production]
GO:0042826 [histone deacetylase binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051880 [G-quadruplex DNA binding]
GO:0070062 [extracellular exosome]
Show all
 994 aa
113.2 kDa 		No 0
DHX36-004
ENSP00000419862
ENST00000481941
E7EWK3 [Direct mapping]
ATP-dependent RNA helicase DHX36
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004386 [helicase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006396 [RNA processing]
GO:0008026 [ATP-dependent helicase activity]
Show all
 797 aa
91.4 kDa 		No 1
DHX36-008
ENSP00000419761
ENST00000469977
H7C5F5 [Direct mapping]
ATP-dependent RNA helicase DHX36
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004386 [helicase activity]
GO:0006396 [RNA processing]
Show all
 188 aa
20.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.