Tissue expression of PARL - Summary - The Human Protein Atlas

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PARL

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PARL
Gene description	Presenilin associated, rhomboid-like
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA019545
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	PARL (HGNC Symbol)
Synonyms	PRO2207, PSARL, PSARL1, RHBDS1
Description	Presenilin associated, rhomboid-like (HGNC Symbol)
Entrez gene summary	This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q27.1
Chromosome location (bp)	183829385 - 183884933
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175193 (version 83.38)
Entrez gene	55486
UniProt	Q9H300 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H300
Antibodypedia	PARL antibodies

PROTEIN BROWSER

PARL-001	PARL-002	PARL-005	PARL-007	PARL-008	PARL-009	PARL-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PARL-001 ENSP00000325421 ENST00000317096	Q9H300 [Direct mapping] Presenilins-associated rhomboid-like protein, mitochondrial P-beta Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004175 [endopeptidase activity] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0030162 [regulation of proteolysis] GO:0033619 [membrane protein proteolysis] GO:0090201 [negative regulation of release of cytochrome c from mitochondria] GO:1903146 [regulation of mitophagy] GO:1903214 [regulation of protein targeting to mitochondrion] GO:2000377 [regulation of reactive oxygen species metabolic process] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] Show all	379 aa 42.2 kDa	No	7
PARL-002 ENSP00000310676 ENST00000311101	Q9H300 [Direct mapping] Presenilins-associated rhomboid-like protein, mitochondrial P-beta Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004175 [endopeptidase activity] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0030162 [regulation of proteolysis] GO:0033619 [membrane protein proteolysis] GO:1903214 [regulation of protein targeting to mitochondrion] GO:2000377 [regulation of reactive oxygen species metabolic process] Show all	329 aa 36.6 kDa	No	5
PARL-005 ENSP00000396691 ENST00000449306	H7C0U0 [Direct mapping] Presenilins-associated rhomboid-like protein, mitochondrial Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] Show all	159 aa 17.6 kDa	No	0
PARL-007 ENSP00000402137 ENST00000435888	C9JNP8 [Direct mapping] Presenilins-associated rhomboid-like protein, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005739 [mitochondrion] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] Show all	295 aa 33.1 kDa	No	3
PARL-008 ENSP00000402689 ENST00000450375	H7C1V6 [Direct mapping] Presenilins-associated rhomboid-like protein, mitochondrial Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] Show all	63 aa 6.8 kDa	No	0
PARL-009 ENSP00000398043 ENST00000417784	H7C122 [Direct mapping] Presenilins-associated rhomboid-like protein, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] Show all	171 aa 18.6 kDa	No	3
PARL-010 ENSP00000392926 ENST00000418450	H7C045 [Direct mapping] Presenilins-associated rhomboid-like protein, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] Show all	112 aa 12.1 kDa	No	1

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The Human Protein Atlas

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