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DDIT3

CANCER ATLAS

Gene description

 DNA-damage-inducible transcript 3

Protein class

 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA068416

GENE INFORMATION

Gene name

 DDIT3 (HGNC Symbol)

Synonyms

 CHOP, CHOP10, GADD153

Description

 DNA-damage-inducible transcript 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]

Chromosome

 12

Cytoband

 q13.3

Chromosome location (bp)

 57516588 - 57520517

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175197 (version 83.38)

Entrez gene

 1649

UniProt

 P35638 (UniProt - Evidence at protein level)

neXtProt

 NX_P35638

Antibodypedia

 DDIT3 antibodies

PROTEIN BROWSER
DDIT3-001
DDIT3-002
DDIT3-004
DDIT3-005
DDIT3-006
DDIT3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DDIT3-001
ENSP00000340671
ENST00000346473
P35638 [Direct mapping]
DNA damage-inducible transcript 3 protein
Q53YD1 [Target identity:100%; Query identity:100%]
DNA damage-inducible transcript 3 protein
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006986 [response to unfolded protein]
GO:0007050 [cell cycle arrest]
GO:0008134 [transcription factor binding]
GO:0008140 [cAMP response element binding protein binding]
GO:0016055 [Wnt signaling pathway]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032792 [negative regulation of CREB transcription factor activity]
GO:0032993 [protein-DNA complex]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035976 [AP1 complex]
GO:0036488 [CHOP-C/EBP complex]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0036500 [ATF6-mediated unfolded protein response]
GO:0042789 [mRNA transcription from RNA polymerase II promoter]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043522 [leucine zipper domain binding]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043620 [regulation of DNA-templated transcription in response to stress]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044267 [cellular protein metabolic process]
GO:0044324 [regulation of transcription involved in anterior/posterior axis specification]
GO:0045454 [cell redox homeostasis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:1902237 [positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1903026 [negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:1990617 [CHOP-ATF4 complex]
GO:1990622 [CHOP-ATF3 complex]
GO:2000016 [negative regulation of determination of dorsal identity]
Show all
 169 aa
19.2 kDa 		No 0
DDIT3-002
ENSP00000448665
ENST00000551116
P35638 [Direct mapping]
DNA damage-inducible transcript 3 protein
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001955 [blood vessel maturation]
GO:0001975 [response to amphetamine]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005770 [late endosome]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006979 [response to oxidative stress]
GO:0006983 [ER overload response]
GO:0006986 [response to unfolded protein]
GO:0007050 [cell cycle arrest]
GO:0007568 [aging]
GO:0007584 [response to nutrient]
GO:0008134 [transcription factor binding]
GO:0008140 [cAMP response element binding protein binding]
GO:0016055 [Wnt signaling pathway]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032792 [negative regulation of CREB transcription factor activity]
GO:0032993 [protein-DNA complex]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035976 [AP1 complex]
GO:0036488 [CHOP-C/EBP complex]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0036500 [ATF6-mediated unfolded protein response]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0042594 [response to starvation]
GO:0042789 [mRNA transcription from RNA polymerase II promoter]
GO:0043065 [positive regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043392 [negative regulation of DNA binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043522 [leucine zipper domain binding]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043620 [regulation of DNA-templated transcription in response to stress]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044267 [cellular protein metabolic process]
GO:0044324 [regulation of transcription involved in anterior/posterior axis specification]
GO:0045454 [cell redox homeostasis]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045662 [negative regulation of myoblast differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048568 [embryonic organ development]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:1901216 [positive regulation of neuron death]
GO:1902237 [positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1903026 [negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:1990617 [CHOP-ATF4 complex]
GO:1990622 [CHOP-ATF3 complex]
GO:2000016 [negative regulation of determination of dorsal identity]
Show all
 192 aa
21.7 kDa 		No 0
DDIT3-004
ENSP00000447503
ENST00000547526
F8W133 [Direct mapping]
DNA damage-inducible transcript 3 protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Show all
 145 aa
16 kDa 		No 0
DDIT3-005
ENSP00000447803
ENST00000552740
P35638 [Direct mapping]
DNA damage-inducible transcript 3 protein
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006986 [response to unfolded protein]
GO:0007050 [cell cycle arrest]
GO:0008134 [transcription factor binding]
GO:0008140 [cAMP response element binding protein binding]
GO:0016055 [Wnt signaling pathway]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032792 [negative regulation of CREB transcription factor activity]
GO:0032993 [protein-DNA complex]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035976 [AP1 complex]
GO:0036488 [CHOP-C/EBP complex]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0036500 [ATF6-mediated unfolded protein response]
GO:0042789 [mRNA transcription from RNA polymerase II promoter]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043522 [leucine zipper domain binding]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043620 [regulation of DNA-templated transcription in response to stress]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044267 [cellular protein metabolic process]
GO:0044324 [regulation of transcription involved in anterior/posterior axis specification]
GO:0045454 [cell redox homeostasis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:1902237 [positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1903026 [negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:1990617 [CHOP-ATF4 complex]
GO:1990622 [CHOP-ATF3 complex]
GO:2000016 [negative regulation of determination of dorsal identity]
Show all
 192 aa
21.7 kDa 		No 0
DDIT3-006
ENSP00000447188
ENST00000547303
P35638 [Direct mapping]
DNA damage-inducible transcript 3 protein
Q53YD1 [Target identity:100%; Query identity:100%]
DNA damage-inducible transcript 3 protein
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006986 [response to unfolded protein]
GO:0007050 [cell cycle arrest]
GO:0008134 [transcription factor binding]
GO:0008140 [cAMP response element binding protein binding]
GO:0016055 [Wnt signaling pathway]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032792 [negative regulation of CREB transcription factor activity]
GO:0032993 [protein-DNA complex]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035976 [AP1 complex]
GO:0036488 [CHOP-C/EBP complex]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0036500 [ATF6-mediated unfolded protein response]
GO:0042789 [mRNA transcription from RNA polymerase II promoter]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043522 [leucine zipper domain binding]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043620 [regulation of DNA-templated transcription in response to stress]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044267 [cellular protein metabolic process]
GO:0044324 [regulation of transcription involved in anterior/posterior axis specification]
GO:0045454 [cell redox homeostasis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:1902237 [positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1903026 [negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:1990617 [CHOP-ATF4 complex]
GO:1990622 [CHOP-ATF3 complex]
GO:2000016 [negative regulation of determination of dorsal identity]
Show all
 169 aa
19.2 kDa 		No 0
DDIT3-201
ENSP00000481270
ENST00000618206
A0A0C4DGW4 [Direct mapping]
DNA damage-inducible transcript 3 protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006986 [response to unfolded protein]
GO:0007050 [cell cycle arrest]
GO:0016055 [Wnt signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 168 aa
19.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.