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MED16

CANCER ATLAS

Gene description

 Mediator complex subunit 16

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA030685

GENE INFORMATION

Gene name

 MED16 (HGNC Symbol)

Synonyms

 DRIP92, THRAP5, TRAP95

Description

 Mediator complex subunit 16 (HGNC Symbol)

Entrez gene summary

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 867630 - 893218

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175221 (version 83.38)

Entrez gene

 10025

UniProt

 Q9Y2X0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y2X0

Antibodypedia

 MED16 antibodies

PROTEIN BROWSER
«
MED16-001
MED16-002
MED16-003
MED16-004
MED16-005
MED16-006
MED16-011
MED16-021
MED16-039
MED16-201
MED16-202
MED16-203
MED16-204
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MED16-001
ENSP00000379153
ENST00000395808
Q9Y2X0 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 16
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003712 [transcription cofactor activity]
GO:0003713 [transcription coactivator activity]
GO:0003824 [catalytic activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016592 [mediator complex]
GO:0030375 [thyroid hormone receptor coactivator activity]
GO:0030518 [intracellular steroid hormone receptor signaling pathway]
GO:0030521 [androgen receptor signaling pathway]
GO:0042809 [vitamin D receptor binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046966 [thyroid hormone receptor binding]
GO:2000273 [positive regulation of receptor activity]
Show all
 841 aa
93 kDa 		No 0
MED16-002
ENSP00000480766
ENST00000606828
B9TX03 [Direct mapping]
Mediator complex subunit MED16 variant MED16_i10; Mediator of RNA polymerase II transcription subunit 16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 194 aa
21.9 kDa 		No 0
MED16-003
ENSP00000308528
ENST00000312090
Q9Y2X0 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 16
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003712 [transcription cofactor activity]
GO:0003713 [transcription coactivator activity]
GO:0003824 [catalytic activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016592 [mediator complex]
GO:0030375 [thyroid hormone receptor coactivator activity]
GO:0030518 [intracellular steroid hormone receptor signaling pathway]
GO:0030521 [androgen receptor signaling pathway]
GO:0042809 [vitamin D receptor binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046966 [thyroid hormone receptor binding]
GO:2000273 [positive regulation of receptor activity]
Show all
 860 aa
95 kDa 		No 0
MED16-004
ENSP00000465827
ENST00000586342
K7EKX6 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 49 aa
5.5 kDa 		No 0
MED16-005
ENSP00000466868
ENST00000592943
B9TWZ6 [Direct mapping]
Mediator complex subunit MED16 variant MED16_i3; Mediator of RNA polymerase II transcription subunit 16
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0008152 [metabolic process]
Show all
 537 aa
58.9 kDa 		No 0
MED16-006
ENSP00000464810
ENST00000589119
Q9Y2X0 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 16
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003712 [transcription cofactor activity]
GO:0003713 [transcription coactivator activity]
GO:0003824 [catalytic activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016592 [mediator complex]
GO:0030375 [thyroid hormone receptor coactivator activity]
GO:0030518 [intracellular steroid hormone receptor signaling pathway]
GO:0030521 [androgen receptor signaling pathway]
GO:0042809 [vitamin D receptor binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046966 [thyroid hormone receptor binding]
GO:2000273 [positive regulation of receptor activity]
Show all
 877 aa
96.8 kDa 		No 0
MED16-011
ENSP00000465762
ENST00000586017
K7EKS6 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 16
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 462 aa
51.5 kDa 		No 0
MED16-021
ENSP00000475725
ENST00000607471
U3KQB4 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 16
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 505 aa
55.4 kDa 		No 0
MED16-039
ENSP00000478286
ENST00000621073
A0A087WU12 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 79 aa
8.6 kDa 		No 0
MED16-201
ENSP00000269814
ENST00000269814
B9TX12 [Direct mapping]
Mediator complex subunit MED16 variant MED16_i19; Mediator of RNA polymerase II transcription subunit 16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 218 aa
24.5 kDa 		No 0
MED16-202
ENSP00000325612
ENST00000325464
Q9Y2X0 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 16
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003712 [transcription cofactor activity]
GO:0003713 [transcription coactivator activity]
GO:0003824 [catalytic activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016592 [mediator complex]
GO:0030375 [thyroid hormone receptor coactivator activity]
GO:0030518 [intracellular steroid hormone receptor signaling pathway]
GO:0030521 [androgen receptor signaling pathway]
GO:0042809 [vitamin D receptor binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046966 [thyroid hormone receptor binding]
GO:2000273 [positive regulation of receptor activity]
Show all
 877 aa
96.8 kDa 		No 0
MED16-203
ENSP00000479411
ENST00000616387
B9TX11 [Direct mapping]
Mediator complex subunit MED16 variant MED16_i18; Mediator of RNA polymerase II transcription subunit 16
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 219 aa
24.1 kDa 		No 0
MED16-204
ENSP00000483533
ENST00000617672
B9TX21 [Direct mapping]
Mediator complex subunit MED16 variant MED16_i28; Mediator of RNA polymerase II transcription subunit 16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 135 aa
14.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.