Tissue expression of APITD1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	APITD1
Gene description	Apoptosis-inducing, TAF9-like domain 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	APITD1 (HGNC Symbol)
Synonyms	CENP-S, CENPS, FAAP16, MHF1
Description	Apoptosis-inducing, TAF9-like domain 1 (HGNC Symbol)
Entrez gene summary	This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (nucleosome distal) complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream cortistatin (CORT) gene, as represented in GeneID:100526739. An APITD1-related pseudogene has been identified on chromosome 7. [provided by RefSeq, Nov 2010]
Chromosome	1
Cytoband	p36.22
Chromosome location (bp)	10430443 - 10442809
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175279 (version 83.38)
Entrez gene	378708
UniProt	Q8N2Z9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N2Z9
Antibodypedia	APITD1 antibodies

PROTEIN BROWSER

APITD1-001	APITD1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APITD1-001 ENSP00000308583 ENST00000309048	Q8N2Z9 [Direct mapping] Centromere protein S Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000712 [resolution of meiotic recombination intermediates] GO:0000777 [condensed chromosome kinetochore] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006334 [nucleosome assembly] GO:0006974 [cellular response to DNA damage stimulus] GO:0007067 [mitotic nuclear division] GO:0007264 [small GTPase mediated signal transduction] GO:0031297 [replication fork processing] GO:0031398 [positive regulation of protein ubiquitination] GO:0034080 [CENP-A containing nucleosome assembly] GO:0036297 [interstrand cross-link repair] GO:0043240 [Fanconi anaemia nuclear complex] GO:0046982 [protein heterodimerization activity] GO:0051301 [cell division] GO:0071821 [FANCM-MHF complex] Show all	138 aa 15.9 kDa	No	0
APITD1-003 ENSP00000489524 ENST00000462462		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		49 aa 5.7 kDa	No	0