Tissue expression of DOLK - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DOLK
Gene description	Dolichol kinase
Protein class	Disease related genes Enzymes Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	DOLK (HGNC Symbol)
Synonyms	DK1, KIAA1094, TMEM15
Description	Dolichol kinase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum. Mutations in this gene are associated with dolichol kinase deficiency.[provided by RefSeq, Apr 2010]
Chromosome	9
Cytoband	q34.11
Chromosome location (bp)	128945530 - 128947619
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175283 (version 83.38)
Entrez gene	22845
UniProt	Q9UPQ8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UPQ8
Antibodypedia	DOLK antibodies

PROTEIN BROWSER

DOLK-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DOLK-001 ENSP00000361667 ENST00000372586	Q9UPQ8 [Direct mapping] Dolichol kinase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004168 [dolichol kinase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006489 [dolichyl diphosphate biosynthetic process] GO:0016310 [phosphorylation] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0043048 [dolichyl monophosphate biosynthetic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	538 aa 59.3 kDa	No	>9