Tissue expression of LSM1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	LSM1
Gene description	LSM1 homolog, mRNA degradation associated
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	LSM1 (HGNC Symbol)
Synonyms	CASM, YJL124C
Description	LSM1 homolog, mRNA degradation associated (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]
Chromosome	8
Cytoband	p11.23
Chromosome location (bp)	38163321 - 38176730
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000175324 (version 83.38)
Entrez gene	27257
UniProt	O15116 (UniProt - Evidence at protein level)
neXtProt	NX_O15116
Antibodypedia	LSM1 antibodies

PROTEIN BROWSER

LSM1-001	LSM1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LSM1-001 ENSP00000310596 ENST00000311351	O15116 [Direct mapping] U6 snRNA-associated Sm-like protein LSm1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000290 [deadenylation-dependent decapping of nuclear-transcribed mRNA] GO:0000339 [RNA cap binding] GO:0000375 [RNA splicing, via transesterification reactions] GO:0000932 [cytoplasmic mRNA processing body] GO:0003729 [mRNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005845 [mRNA cap binding complex] GO:0006397 [mRNA processing] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0019827 [stem cell population maintenance] GO:0030424 [axon] GO:0030425 [dendrite] GO:0036002 [pre-mRNA binding] GO:0043025 [neuronal cell body] GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay] GO:0044822 [poly(A) RNA binding] GO:0045665 [negative regulation of neuron differentiation] GO:0071044 [histone mRNA catabolic process] GO:1990124 [messenger ribonucleoprotein complex] GO:1990726 [Lsm1-7-Pat1 complex] Show all	133 aa 15.2 kDa	No	0
LSM1-002 ENSP00000430021 ENST00000520755	E5RH18 [Direct mapping] U6 snRNA-associated Sm-like protein LSm1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		44 aa 4.9 kDa	No	0